Effects of statin therapy on the progression of chronic kidney disease

Samir Shah, James Paparello, Farhad R. Danesh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Statins are lipid-lowering agents that specifically, competitively, and reversibly inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in the formation of cholesterol. A large body of evidence from numerous, well-controlled, randomized trials demonstrates that statins significantly reduce fatal and nonfatal cardiovascular events in the general population. Cardiovascular benefits of statins have been conventionally attributed to reduction in levels of low-density lipoprotein cholesterol. More recently, subanalyses of large clinical trials suggest that statins may also prove beneficial in ameliorating the progression of kidney disease through their cholesterol-dependent and/or cholesterol-independent (pleiotropic) effects. This review focuses on the role of statin therapy in the progression of chronic kidney disease, the published trials that study the effect of antilipidemic agents on nephropathy, and the emerging pleiotropic effects of statins on the kidneys.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalAdvances in Chronic Kidney Disease
Volume12
Issue number2
DOIs
StatePublished - Apr 2005

Keywords

  • Cardiovascular disease
  • Cholesterol
  • Chronic renal disease
  • Dyslipidemia
  • Statin

ASJC Scopus subject areas

  • Nephrology

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