Effects of stress and stress hormones on amyloid-\beta protein and plaque deposition

Hongxin Dong*, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


Growing evidence indicates that physical and psychosocial stressors, in part acting through the hypothalamic-pituitary-adrenal (HPA) axis, may accelerate the process of Alzheimer's disease (AD). In this review, we summarize recent research related to the effects of stress and stress hormones on the various disease process elements associated with AD. Specifically, we focus on the relationships among chronic stressors, HPA axis activity, amyloid-β protein, and amyloid-β plaque deposition in mouse models of AD. The potential mechanisms by which stress and stress-related components, especially corticotrophin-releasing factor and its receptors, influence the pathogenesis of AD are discussed.

Original languageEnglish (US)
Pages (from-to)459-469
Number of pages11
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2009


  • Alzheimer's disease
  • Amyloid-β
  • Corticotrophin-releasing factor (CRF) and receptors (CRFRs)
  • Hypothalamic-pituitary-adrenal (HPA) axis
  • Stress
  • Tg2576 mice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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