Effects of surgical ventricular restoration on left ventricular function: Dynamic MR imaging

Brett B. Carmichael, Randolph M. Setser, Arthur E. Stillman, Michael L. Lieber, Nicholas G. Smedira, Patrick M. McCarthy, Randall C. Starling, James B. Young, Joan A. Weaver, Angel G. Lawrence, Richard D. White*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: To retrospectively evaluate with dynamic magnetic resonance (MR) imaging the changes in global and regional left ventricular (LV) function after surgical ventricular restoration (SVR) performed in chronic ischemic heart disease patients with large nonaneurysmal or aneurysmal postmyocardial infarction zones. Materials and Methods: The study was performed with institutional review board approval, and a waiver of individual informed consent was obtained. The study was HIPAA compliant. Patients (83 men, 22 women; mean age, 61 years ± 9 [standard deviation]) were evaluated with MR imaging before and after SVR as follows: pre-SVR examination (n = 105; 25 days ± 39 before SVR; median, 7 days; range, 1-189 days), early post-SVR examination (n = 95, 7 days ± 3 after SVR), and late post-SVR (n = 35, 313 days ± 158 after SVR). Cine MR imaging allowed calculation of ejection fraction and rate-corrected velocity of circumferential fiber shortening (VcfC) for global LV functional evaluation, whereas tagged MR imaging (spatial modulation of magnetization with harmonic phase analysis) permitted assessment of regional circumferential strain (EC) with coronary distribution. VcfC and EC were computed at both LV base- and mid-LV short-axis levels remote from the site of anteroapical SVR. Results: Prior to SVR, LV dilatation and diminished global and regional LV function were observed. At early post-SVR examination, VcfC had improved significantly but EC showed a worsening trend overall, although only EC of the right coronary artery at the mid-LV level worsened significantly. At late post-SVR examination, VcfC values were improved when compared with pre-SVR values, although EC showed no statistically significant improvement. When compared with that at early post-SVR examination, however, EC showed significant improvement in two segments: left anterior descending artery and right coronary artery at mid-LV level. Conclusion: Although volume-based indexes of global LV function improve significantly after SVR, regional LV function did not improve significantly; there was evidence of continued LV remodeling after SVR.

Original languageEnglish (US)
Pages (from-to)710-717
Number of pages8
Issue number3
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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