TY - JOUR
T1 - Effects of the newer nonsteroidal anti-inflammatory agents, ibuprofen, fenoprofen, and sulindac, on neutrophil adherence
AU - Venezio, Frank R.
AU - Di Vincenzo, Cathy
AU - Pearlman, Fred
AU - Phair, John P.
N1 - Funding Information:
Receivedfor publication 28 January 1985,and in revised form 8 April 1985. This work was presented in part at the 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy, held in Las Vegas, Nevada, in October 1983. Informed consent was obtained from the volunteers in accordance with the guidelines for human experimentation of the U.S. Department of Health and Human Services and the Loyola University Stritch School of Medicine Institutional ReviewBoard. These studies were supported by funds from the Upjohn and Eli Lilly Companies. Please address requests for reprints to Dr. Frank R. Venezio, Section of Infectious Diseases, Loyola University Stritch School of Medicine, 2160South First Avenue, Maywood, Illinois 60153.
PY - 1985/10/1
Y1 - 1985/10/1
N2 - Administration of corticosteroids, aspirin, or indomethacin induces marked inhibition of adherence of polymorphonuclear leukocytes (PMNLs) in vitro. The effects of three newer nonsteroidal anti-inflammatory agents on PMNL adherence were defined. Adherence of PMNLs after passage through a nylon-woolcolumn wasmeasured in normal volunteers who had ingested a single tablet of 300 mg of ibuprofen, 300 mg of fenoprofen, or 200 mg of sulindac. Adherence was significantly decreased from baseline at 4 hr after ibuprofen or fenoprofen was taken, remained suppressed at 24 hr, and returned to normal at 48 hr. Sulindac mildly inhibited PMNL adherence 48 hr after drug ingestion. Inhibition of adherence with ibuprofen and fenoprofen also occurred after incubation of control PMNLs with plasma specimens from volunteers 4 and 24 hr after drug administration, a result suggesting a partially plasma-mediated factor. Zymosan-induced augmented adherence was also inhibited by pretreatment in vitro with ibuprofen at a concentration of 25 μg/ml and fenoprofen at 50 μg/ml.
AB - Administration of corticosteroids, aspirin, or indomethacin induces marked inhibition of adherence of polymorphonuclear leukocytes (PMNLs) in vitro. The effects of three newer nonsteroidal anti-inflammatory agents on PMNL adherence were defined. Adherence of PMNLs after passage through a nylon-woolcolumn wasmeasured in normal volunteers who had ingested a single tablet of 300 mg of ibuprofen, 300 mg of fenoprofen, or 200 mg of sulindac. Adherence was significantly decreased from baseline at 4 hr after ibuprofen or fenoprofen was taken, remained suppressed at 24 hr, and returned to normal at 48 hr. Sulindac mildly inhibited PMNL adherence 48 hr after drug ingestion. Inhibition of adherence with ibuprofen and fenoprofen also occurred after incubation of control PMNLs with plasma specimens from volunteers 4 and 24 hr after drug administration, a result suggesting a partially plasma-mediated factor. Zymosan-induced augmented adherence was also inhibited by pretreatment in vitro with ibuprofen at a concentration of 25 μg/ml and fenoprofen at 50 μg/ml.
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U2 - 10.1093/infdis/152.4.690
DO - 10.1093/infdis/152.4.690
M3 - Article
C2 - 4045229
AN - SCOPUS:0022356269
SN - 0022-1899
VL - 152
SP - 690
EP - 694
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -
