Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro

B. Wang; Zhi-Dong Ge; A. W. Zhou; M. Z. Chen; S. Y. Xu

Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro

B. Wang^*, Zhi-Dong Ge, A. W. Zhou, M. Z. Chen, S. Y. Xu

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

AIM: To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro. METHODS: T lymphocyte proliferation and its interleukin 2 (IL-2) secretion, B lymphocyte proliferation, IL-1 production by peritoneal macrophages were measured by [³H]-TdR incorporation. RESULTS: TGM 2~50 mg · L^-1 could significantly promote murine T lympocyte proliferation and IL-2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL-1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration-effect curves showed the bell- shaped. CONCLUSION: TGM has a dual immunomodulatory activity in a concentration-related way.

Original language	English (US)
Pages (from-to)	63-65
Number of pages	3
Journal	Chinese Pharmacological Bulletin
Volume	15
Issue number	1
State	Published - 1999

Keywords

B lymphocytes
Immune functions
Macrophages
T lymphocytes
Total glucosides of mudan cortex

ASJC Scopus subject areas

Pharmacology

Cite this

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title = "Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro",

abstract = "AIM: To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro. METHODS: T lymphocyte proliferation and its interleukin 2 (IL-2) secretion, B lymphocyte proliferation, IL-1 production by peritoneal macrophages were measured by [3H]-TdR incorporation. RESULTS: TGM 2~50 mg · L-1 could significantly promote murine T lympocyte proliferation and IL-2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL-1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration-effect curves showed the bell- shaped. CONCLUSION: TGM has a dual immunomodulatory activity in a concentration-related way.",

keywords = "B lymphocytes, Immune functions, Macrophages, T lymphocytes, Total glucosides of mudan cortex",

author = "B. Wang and Zhi-Dong Ge and Zhou, {A. W.} and Chen, {M. Z.} and Xu, {S. Y.}",

year = "1999",

language = "English (US)",

volume = "15",

pages = "63--65",

journal = "Chinese Pharmacological Bulletin",

issn = "1001-1978",

publisher = "Institute of Clinical Pharmacology",

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TY - JOUR

T1 - Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro

AU - Wang, B.

AU - Ge, Zhi-Dong

AU - Zhou, A. W.

AU - Chen, M. Z.

AU - Xu, S. Y.

PY - 1999

Y1 - 1999

N2 - AIM: To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro. METHODS: T lymphocyte proliferation and its interleukin 2 (IL-2) secretion, B lymphocyte proliferation, IL-1 production by peritoneal macrophages were measured by [3H]-TdR incorporation. RESULTS: TGM 2~50 mg · L-1 could significantly promote murine T lympocyte proliferation and IL-2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL-1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration-effect curves showed the bell- shaped. CONCLUSION: TGM has a dual immunomodulatory activity in a concentration-related way.

AB - AIM: To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro. METHODS: T lymphocyte proliferation and its interleukin 2 (IL-2) secretion, B lymphocyte proliferation, IL-1 production by peritoneal macrophages were measured by [3H]-TdR incorporation. RESULTS: TGM 2~50 mg · L-1 could significantly promote murine T lympocyte proliferation and IL-2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL-1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration-effect curves showed the bell- shaped. CONCLUSION: TGM has a dual immunomodulatory activity in a concentration-related way.

KW - B lymphocytes

KW - Immune functions

KW - Macrophages

KW - T lymphocytes

KW - Total glucosides of mudan cortex

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JO - Chinese Pharmacological Bulletin

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Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro

Abstract

Keywords

ASJC Scopus subject areas

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