Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro

B. Wang*, Zhi-Dong Ge, A. W. Zhou, M. Z. Chen, S. Y. Xu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

AIM: To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro. METHODS: T lymphocyte proliferation and its interleukin 2 (IL-2) secretion, B lymphocyte proliferation, IL-1 production by peritoneal macrophages were measured by [3H]-TdR incorporation. RESULTS: TGM 2~50 mg · L-1 could significantly promote murine T lympocyte proliferation and IL-2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL-1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration-effect curves showed the bell- shaped. CONCLUSION: TGM has a dual immunomodulatory activity in a concentration-related way.

Original languageEnglish (US)
Pages (from-to)63-65
Number of pages3
JournalChinese Pharmacological Bulletin
Volume15
Issue number1
StatePublished - Jan 1 1999

Keywords

  • B lymphocytes
  • Immune functions
  • Macrophages
  • T lymphocytes
  • Total glucosides of mudan cortex

ASJC Scopus subject areas

  • Pharmacology

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