Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary report

Michael Weiner, Danielle Harvey, Jacqueline Hayes, Susan Landau, Paul Aisen, Ronald Petersen, Duygu Tosun, Dallas Veitch, Clifford Jack, Charles Decarli, Andrew Saykin, Jordan Grafman, Thomas Neylan

Research output: Contribution to journalArticle

23 Scopus citations


Introduction Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have previously been reported to be associated with increased risk of Alzheimer's disease (AD). We are using biomarkers to study Vietnam Veterans with/without mild cognitive impairment with a history of at least one TBI and/or ongoing PTSD to determine whether these contribute to the development of AD. Methods Potential subjects identified by Veterans Administration records underwent an initial telephone screen. Consented subjects underwent clinical evaluation, lumbar puncture, structural magnetic resonance imaging, and amyloid positron emission tomography (PET) scans. Results We observed worse cognitive functioning in PTSD and TBI + PTSD groups, worse global cognitive functioning in the PTSD group, lower superior parietal volume in the TBI + PTSD group, and lower amyloid positivity in the PTSD group, but not the TBI group compared to controls without TBI/PTSD. Medial temporal lobe atrophy was not increased in the PTSD and/or TBI groups. Discussion Preliminary results do not indicate that TBI or PTSD increase the risk for AD measured by amyloid PET. Additional recruitment, longitudinal follow-up, and tau-PET scans will provide more information in the future.

Original languageEnglish (US)
Pages (from-to)177-188
Number of pages12
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Issue number2
StatePublished - Jun 1 2017



  • Alzheimer's disease
  • Mild cognitive impairment
  • Posttraumatic stress disorder
  • Traumatic brain injury
  • Vietnam veterans

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this