Effects of trigeminal tractotomy on facial thermal nociception in the rat

James G. Broton*, J. Peter Rosenfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Wire knife-cuts lesioning the descending trigeminal tract and trigeminal sensory nuclear complex at the level of subnucleus interpolaris significantly elevated response latencies to noxious thermal stimuli applied to one perioral locus of facial skin. Group analyses of four other ipsilateral sites did not reveal significant effects. Medial cuts, extensively damaging the sensory nuclear complex as well as the tract, were more likely to produce significant elevations than were lateral cuts. These results suggest that tractotomy does not result in complete facial analgesia in the rat, and that the effectiveness of tractotomy may in part be due to interruption of intranuclear trigeminal projections.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalBrain research
Volume333
Issue number1
DOIs
StatePublished - Apr 29 1985

Keywords

  • behavior
  • face-rub response
  • nociception
  • rat
  • tractotomy
  • trigeminal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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