Effects of uniform anisotropy on wavelet fractionation and electrogram simulations in a computer model of fibrillation

Using a 10,000-element modified Moe computer model of a fibrillating cardiac tissue sheet, cases of isotropic and uniformly anisotropic conduction were implemented and compared to determine how uniform anisotropy contributes to wavelet fractionation. In this model, a bipolar electrogram calculation based on the Ploney volume-conductor equations is implemented in several simple test cases and in a fibrillating, isotropic model sheet. It is shown that in this computer model, the role of uniform anisotropy in wavelet fractionation is less significant than effects due to overall velocity changes. Bipolar recordings in this model can approximate many characteristics in both the time and frequency domains of fibrillating cardiac tissue.