@article{4c317eae6af44d14994f7ee5b57b31cc,
title = "Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of in Vitro Multicomponent Interpenetrating Cytoskeletal Networks",
abstract = "We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with little contribution from either microtubules or vimentin. However, vimentin dramatically impacts the relaxation, with even small amounts significantly increasing the relaxation time of the interpenetrating network. This highly unusual decoupling between dissipation and elasticity may reflect weak attractive interactions between vimentin and actin networks.",
author = "Yinan Shen and Huayin Wu and Lu, {Peter J.} and Dianzhuo Wang and Marjan Shayegan and Hui Li and Weichao Shi and Zizhao Wang and Cai, {Li Heng} and Jing Xia and Meng Zhang and Ruihua Ding and Harald Herrmann and Robert Goldman and Mackintosh, {Fred C.} and Arturo Moncho-Jord{\'a} and Weitz, {David A.}",
note = "Funding Information: We gratefully acknowledge Thomas C. Ferrante and Xinyu Li for help with collection and analysis of microrheology data, and Adrian Pegoraro and Sijie Sun for valuable discussions. This work was supported by the NIH (2P01GM096971, 5P01HL120839), the Harvard MRSEC (DMR-1420570), the Harvard NSF-Simons Center for Mathematical and Statistical Analysis of Biology supported by NSF (DMS-1764269), and the Harvard FAS Quantitative Biology Initiative. F. C. M. acknowledges NSF DMR-1826623 and NSF PHY-2019745. A. M.-J. thanks the Fulbright Program in Spain and the “Plan Andaluz de Investigaci{\'o}n, Desarrollo e Innovaci{\'o}n” of the Junta de Andaluc{\'i}a (Project PY20_00241) for financial support. M. S. thanks the Fonds de recherche du Qu{\'e}bec—Nature et technologies (FRQNT) for funding. Publisher Copyright: {\textcopyright} 2021 American Physical Society.",
year = "2021",
month = sep,
day = "3",
doi = "10.1103/PhysRevLett.127.108101",
language = "English (US)",
volume = "127",
journal = "Physical Review Letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "10",
}