Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of in Vitro Multicomponent Interpenetrating Cytoskeletal Networks

Yinan Shen, Huayin Wu, Peter J. Lu, Dianzhuo Wang, Marjan Shayegan, Hui Li, Weichao Shi, Zizhao Wang, Li Heng Cai, Jing Xia, Meng Zhang, Ruihua Ding, Harald Herrmann, Robert Goldman, Fred C. Mackintosh, Arturo Moncho-Jordá, David A. Weitz

Research output: Contribution to journalArticlepeer-review

Abstract

We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with little contribution from either microtubules or vimentin. However, vimentin dramatically impacts the relaxation, with even small amounts significantly increasing the relaxation time of the interpenetrating network. This highly unusual decoupling between dissipation and elasticity may reflect weak attractive interactions between vimentin and actin networks.

Original languageEnglish (US)
Article number108101
JournalPhysical review letters
Volume127
Issue number10
DOIs
StatePublished - Sep 3 2021

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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