Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

Carla M. Yuede*, Scott D. Zimmerman, Hongxin Dong, Matthew J. Kling, Adam W. Bero, David M. Holtzman, Benjamin F. Timson, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticle

149 Scopus citations


We examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble Aβ levels in brain tissue in the Tg2576 mouse model of Alzheimer's disease (AD). Voluntary running animals spent more time investigating a novel object in a recognition memory paradigm than all other groups. Also, voluntary running animals showed fewer thioflavine S stained plaques than all other groups, whereas forced running animals showed an intermediate number of plaques between voluntary running and sedentary animals. Both voluntary and forced running animals had larger hippocampal volumes than sedentary animals. However, levels of soluble Aβ-40 or Aβ-42 did not significantly differ among groups. The results indicate that voluntary exercise may be superior to forced exercise for reducing certain aspects of AD-like deficits - i.e., plaque deposition and memory impairment, in a mouse model of AD.

Original languageEnglish (US)
Pages (from-to)426-432
Number of pages7
JournalNeurobiology of Disease
Issue number3
StatePublished - Sep 1 2009



  • Alzheimer's disease
  • Forced exercise
  • Hippocampal volume
  • Object recognition
  • Tg2576
  • Voluntary exercise

ASJC Scopus subject areas

  • Neurology

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