@inproceedings{52804212ba3f4c068b011690bed16010,
title = "Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo",
abstract = "Due to wavelength-dependent optical attenuation in the skin, the local fluence at a subcutaneous vessel varies with the optical wavelength in a spectral measurement. Hence compensation for such a spectral attenuation is necessary in quantitative measurements of the oxygen saturation of hemoglobin (sO2) in blood vessels in vivo using photoacoustic (PA) imaging. Here, by employing a simplified double-layer skin model, we find that although the absolute value of sO2 in a vessel is seriously affected by the volume fraction of blood and the spatially averaged sO2 in the dermis, the difference of sO2 between neighboring vessels is minimally affected. Based on in vivo experiments, we demonstrate that the difference in sO2 between a typical artery and a typical vein is conserved before and after an experimentally acquired spectral compensation. This conservation holds regardless of the animal's systemic physiological state.",
keywords = "Fluence attenuation, Hemoglobin oxygen saturation, Photoacoustic microscopy",
author = "Zhang, {Hao F.} and Konstantin Maslov and Wang, {Lihong V.}",
year = "2008",
doi = "10.1117/12.761984",
language = "English (US)",
isbn = "9780819470317",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 ; Conference date: 20-01-2008 Through 23-01-2008",
}