Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo

Hao F. Zhang, Konstantin Maslov, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Due to wavelength-dependent optical attenuation in the skin, the local fluence at a subcutaneous vessel varies with the optical wavelength in a spectral measurement. Hence compensation for such a spectral attenuation is necessary in quantitative measurements of the oxygen saturation of hemoglobin (sO2) in blood vessels in vivo using photoacoustic (PA) imaging. Here, by employing a simplified double-layer skin model, we find that although the absolute value of sO2 in a vessel is seriously affected by the volume fraction of blood and the spatially averaged sO2 in the dermis, the difference of sO2 between neighboring vessels is minimally affected. Based on in vivo experiments, we demonstrate that the difference in sO2 between a typical artery and a typical vein is conserved before and after an experimentally acquired spectral compensation. This conservation holds regardless of the animal's systemic physiological state.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOIs
StatePublished - 2008
Event9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 - San Jose, CA, United States
Duration: Jan 20 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6856
ISSN (Print)1605-7422

Other

Other9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008
CountryUnited States
CitySan Jose, CA
Period1/20/081/23/08

Keywords

  • Fluence attenuation
  • Hemoglobin oxygen saturation
  • Photoacoustic microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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