Efficacy and safety of etanercept in children and adolescents aged ≥ 8 years with severe plaque psoriasis

Ian Landells, Amy S. Paller, David Pariser, Gregory Kricorian, Joanne Foehl, Charles Molta*, Bruce Freundlich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Etanercept, a fully human soluble tumor necrosis factor (TNF)-α receptor, is approved in Europe for treatment of severe plaque psoriasis in children ≥ 8 years. The efficacy and safety of etanercept for this population was evaluated in a retrospective analysis of a previous study, which included 211 children (4-17 years) with psoriasis involving ≥ 10% body surface area and Psoriasis Area and Severity Index (PASI) ≥ 12. In this subanalysis, subjects aged 8-17 years received once-weekly subcutaneous etanercept 0.8 mg/kg (≤ 50 mg) or placebo in double-blind fashion for 12 weeks, followed by 24 weeks of open-label etanercept. Baseline demographics and disease characteristics were similar across treatment arms (etanercept n = 95, placebo n = 97). At week 12, 54.7% subjects receiving etanercept versus 11.3% receiving placebo achieved 75% or greater improvement in PASI (PASI 75) compared with baseline (p < 0.001). PASI 50, PASI 90, and static Physician Global Assessment of psoriasis followed a similar pattern (p < 0.001). Efficacy during the open-label phase was sustained through Week 36. Exposure-adjusted rates of adverse events for etanercept were similar or lower than those for placebo. No appreciable differences were noted in the efficacy and safety profiles between the subjects aged ≥ 8 years in this analysis and those in the original study population aged 4-17 years. In conclusion, etanercept provided significant, sustained improvement in disease severity and was well tolerated in children ≥ 8 years with severe plaque psoriasis.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalEuropean Journal of Dermatology
Volume20
Issue number3
DOIs
StatePublished - May 1 2010

Keywords

  • Etanercept
  • Pediatric
  • Plaque psoriasis
  • TNF blocker

ASJC Scopus subject areas

  • Dermatology

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