Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: A 13-week prospective, randomized, multicenter study

Keyphrases

• Prospective Randomized Trial 100%
• Knee Osteoarthritis 100%
• Naproxcinod 100%
• Placebo 50%
• Naproxen 50%
• Osteoarthritis 16%
• Clinical Trials 8%
• Pain Assessment 8%
• Nitric Oxide 8%
• Blood Pressure 8%
• Clinical Efficacy 8%
• High Incidence 8%
• Adverse Events 8%
• Physical Function 8%
• Overall Safety 8%
• Cyclooxygenase-1 (COX-1) 8%
• Active Groups 8%
• Twice Daily 8%
• Placebo Groups 8%
• Pressure Effect 8%
• Lack of Efficacy 8%
• Clinical Safety 8%
• Disease Status 8%
• Efficacy Index 8%
• Likert Scale 8%
• Intent-to-treat 8%
• Overall Rating 8%
• Western Ontario 8%
• Co-primary Endpoints 8%
• WOMAC 8%
• Blood Pressure Profile 8%
• Increased Blood Pressure 8%
• Donator 8%
• Main-secondary 8%
• Endpoint Results 8%

Medicine and Dentistry

• Osteoarthritis 100%
• Naproxcinod 100%
• Knee 100%
• Placebo 58%
• Naproxen 50%
• Blood Pressure 16%
• Physical Disease by Body Function 16%
• Diseases 8%
• Adverse Event 8%
• Prostaglandin Synthase 8%
• Intention-to-Treat Analysis 8%
• Nitric Oxide 8%
• Likert Scale 8%
• Western Ontario and McMaster Universities Osteoarthritis Index 8%
• Elevated Blood Pressure 8%
• Clinical Trial 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Osteoarthritis 100%
• Naproxcinod 100%
• Placebo 58%
• Naproxen 50%
• Physical Disease by Body Function 16%
• Clinical Trial 8%
• Adverse Event 8%
• Prostaglandin Synthase 8%
• Elevated Blood Pressure 8%
• Disease 8%
• Nitric Oxide 8%