Valutazione dell'efficacia di un preparato topico associato ad un integratore dietetico sui segni dell'invecchiamento cutaneo: Studio clinico su 40 donne in premenopausa e/o menopausa

Menopause is a physiological condition that usually occurs in women aged between 40 and 50 years. It is characterized by a decrease of estrogen levels affecting, with various morphological and functional effects, many organs including the skin. Estrogens effects on the skin are expressed by increased epidermal proliferation and dermal collagen and hyaluronic acid production, and increase of cutaneous vascularization. All these factors may lead to an improvement of skin thickness and of dermal hydroscopic qualities. On the other hand, a reduction of estrogens levels may cause skin atrophy, dryness and a decrease in skin elasticity leading to increasead skin wrinkling and alterated pigmentation. In the last few years, skin aging has become an area of increased research interest, with particular focus on menopause. In order to evaluate the efficacy and tolerability of a new antiaging treatment consisting of a topic emulsion and an oral supplement forty women, aged between 45 and 55 were evaluated. The patients were assigned to two groups, of twenty subjects each, group A and Group B respectively. The patients from group A were instructed to apply the topical emulsion twice a day and to take the oral supplement in the morning, while the patients from group B used the topical emulsion only. The aim of our study was to evaluate if the combination treatment (topic + supplement) had more efficacy than the topic alone. Four parameters such as hydratation, swelling, brightness and skin color uniformity were considered. Clinical, digital and ultrasound examination were performed to evaluate treatment response. Self assessment was obtained by patients questionnaires. An improvement of all parameters was observed in all patients. Patients from group A, that used both topic and oral supplement, showed better results. Ultrasound evaluation showed an increased skin echogenicity in both groups, more evident in group A.