Efficacy of a mephentermine-based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle

D. N.Q. Cunha*, C. L. del Rio, B. L. Youngblood, E. L. Ferris, G. E. Geist, Y. Ueyama, L. C. Franz, S. Mathur, R. L. Hamlin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY® INJETÁVEL (POT), a mephentermine-based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized-complete-block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume-matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six-day washout period, cattle received the opposite compound. Animals were anesthetized and catheterized for systemic/left ventricular hemodynamic monitoring. Myocardial dysfunction/hypotension was induced by increasing the end-tidal isoflurane concentration until arterial blood pressure was 20% lower than at baseline and remained stable. Once the animal was determined to be hypotensive and hemodynamically stable, steady-state hypotensive baseline data (BL2) were acquired, and treatment with either POT or CP was given. Data were acquired post-treatment at every 15 min for 90 min. POT improved cardiac output (+68 L/min, ±14%, p < 0.05), MAP (+14 mmHg, ±4%, p < 0.05), HR (+22 bpm, ±8%, p < 0.05), and peak rates of ventricular pressure change during both systole (dP/dtmax: +37 mmHg/s ±13%, p < 0.05) and diastole (dP/dtmin: +31 mmHg/s, ±7%, p < 0.05). No improvements were noted following placebo-control administration. Results indicate that POT improves cardiac performance and systemic hemodynamics in cattle with induced cardiovascular depression when given as single intramuscular injection.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume41
Issue number2
DOIs
StatePublished - Apr 2018
Externally publishedYes

Keywords

  • blood pressure
  • bovine
  • hemodynamics
  • inotropic
  • mephentermine

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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