Efficacy of a needling device for the treatment of acne scars

A randomized clinical trial

Murad Alam*, Sandra Han, Marisa Pongprutthipan, Wareeporn Disphanurat, Rohit Kakar, Michael Nodzenski, Natalie Pace, Natalie Kim, Simon S Yoo, Emir Veledar, Emily Poon Samuelson, Dennis P West

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

Original languageEnglish (US)
Pages (from-to)844-849
Number of pages6
JournalJAMA dermatology
Volume150
Issue number8
DOIs
StatePublished - Jan 1 2014

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Acne Vulgaris
Cicatrix
Randomized Controlled Trials
Equipment and Supplies
Therapeutics
Pain
Control Groups
Needles
Placebos
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Alam, Murad ; Han, Sandra ; Pongprutthipan, Marisa ; Disphanurat, Wareeporn ; Kakar, Rohit ; Nodzenski, Michael ; Pace, Natalie ; Kim, Natalie ; Yoo, Simon S ; Veledar, Emir ; Samuelson, Emily Poon ; West, Dennis P. / Efficacy of a needling device for the treatment of acne scars : A randomized clinical trial. In: JAMA dermatology. 2014 ; Vol. 150, No. 8. pp. 844-849.
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abstract = "IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95{\%} CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95{\%} CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95{\%} CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95{\%} CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41{\%} mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.",
author = "Murad Alam and Sandra Han and Marisa Pongprutthipan and Wareeporn Disphanurat and Rohit Kakar and Michael Nodzenski and Natalie Pace and Natalie Kim and Yoo, {Simon S} and Emir Veledar and Samuelson, {Emily Poon} and West, {Dennis P}",
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Alam, M, Han, S, Pongprutthipan, M, Disphanurat, W, Kakar, R, Nodzenski, M, Pace, N, Kim, N, Yoo, SS, Veledar, E, Samuelson, EP & West, DP 2014, 'Efficacy of a needling device for the treatment of acne scars: A randomized clinical trial', JAMA dermatology, vol. 150, no. 8, pp. 844-849. https://doi.org/10.1001/jamadermatol.2013.8687

Efficacy of a needling device for the treatment of acne scars : A randomized clinical trial. / Alam, Murad; Han, Sandra; Pongprutthipan, Marisa; Disphanurat, Wareeporn; Kakar, Rohit; Nodzenski, Michael; Pace, Natalie; Kim, Natalie; Yoo, Simon S; Veledar, Emir; Samuelson, Emily Poon; West, Dennis P.

In: JAMA dermatology, Vol. 150, No. 8, 01.01.2014, p. 844-849.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of a needling device for the treatment of acne scars

T2 - A randomized clinical trial

AU - Alam, Murad

AU - Han, Sandra

AU - Pongprutthipan, Marisa

AU - Disphanurat, Wareeporn

AU - Kakar, Rohit

AU - Nodzenski, Michael

AU - Pace, Natalie

AU - Kim, Natalie

AU - Yoo, Simon S

AU - Veledar, Emir

AU - Samuelson, Emily Poon

AU - West, Dennis P

PY - 2014/1/1

Y1 - 2014/1/1

N2 - IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

AB - IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

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