Efficacy of a needling device for the treatment of acne scars: A randomized clinical trial

Murad Alam*, Sandra Han, Marisa Pongprutthipan, Wareeporn Disphanurat, Rohit Kakar, Michael Nodzenski, Natalie Pace, Natalie Kim, Simon Yoo, Emir Veledar, Emily Poon, Dennis P. West

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

Original languageEnglish (US)
Pages (from-to)844-849
Number of pages6
JournalJAMA dermatology
Volume150
Issue number8
DOIs
StatePublished - 2014

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Acne Vulgaris
Cicatrix
Randomized Controlled Trials
Equipment and Supplies
Therapeutics
Pain
Control Groups
Needles
Placebos
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Alam, Murad ; Han, Sandra ; Pongprutthipan, Marisa ; Disphanurat, Wareeporn ; Kakar, Rohit ; Nodzenski, Michael ; Pace, Natalie ; Kim, Natalie ; Yoo, Simon ; Veledar, Emir ; Poon, Emily ; West, Dennis P. / Efficacy of a needling device for the treatment of acne scars : A randomized clinical trial. In: JAMA dermatology. 2014 ; Vol. 150, No. 8. pp. 844-849.
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title = "Efficacy of a needling device for the treatment of acne scars: A randomized clinical trial",
abstract = "IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95{\%} CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95{\%} CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95{\%} CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95{\%} CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41{\%} mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.",
author = "Murad Alam and Sandra Han and Marisa Pongprutthipan and Wareeporn Disphanurat and Rohit Kakar and Michael Nodzenski and Natalie Pace and Natalie Kim and Simon Yoo and Emir Veledar and Emily Poon and West, {Dennis P.}",
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Alam, M, Han, S, Pongprutthipan, M, Disphanurat, W, Kakar, R, Nodzenski, M, Pace, N, Kim, N, Yoo, S, Veledar, E, Poon, E & West, DP 2014, 'Efficacy of a needling device for the treatment of acne scars: A randomized clinical trial', JAMA dermatology, vol. 150, no. 8, pp. 844-849. https://doi.org/10.1001/jamadermatol.2013.8687

Efficacy of a needling device for the treatment of acne scars : A randomized clinical trial. / Alam, Murad; Han, Sandra; Pongprutthipan, Marisa; Disphanurat, Wareeporn; Kakar, Rohit; Nodzenski, Michael; Pace, Natalie; Kim, Natalie; Yoo, Simon; Veledar, Emir; Poon, Emily; West, Dennis P.

In: JAMA dermatology, Vol. 150, No. 8, 2014, p. 844-849.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of a needling device for the treatment of acne scars

T2 - A randomized clinical trial

AU - Alam, Murad

AU - Han, Sandra

AU - Pongprutthipan, Marisa

AU - Disphanurat, Wareeporn

AU - Kakar, Rohit

AU - Nodzenski, Michael

AU - Pace, Natalie

AU - Kim, Natalie

AU - Yoo, Simon

AU - Veledar, Emir

AU - Poon, Emily

AU - West, Dennis P.

PY - 2014

Y1 - 2014

N2 - IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

AB - IMPORTANCE: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars. OBJECTIVE: To determine the efficacy of a needling device for treatment of acne scars. DESIGN, SETTING, AND PARTICIPANTS: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution. The study took place from November 30, 2009, through July 27, 2010. Twenty healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled. Fifteen individuals completed the study, and no enrolled participants were withdrawn for adverse effects. INTERVENTIONS: For each participant, one side of the face was randomized for needling. Three needling treatments were performed at 2-week intervals. MAIN OUTCOMES AND MEASURES: Two blinded dermatologists separately rated participants' acne scars based on standard digital photographs obtained at baseline and at the 3-month and 6-month follow-up visits on the quantitative global scarring grading system. RESULTS: Mean scar scores were significantly lower in the treatment group compared with baseline at 6 months (mean difference, 3.4; 95% CI, 0.2-6.5; P = .03) and nominally but not significantly lower compared with baseline at 3 months (mean difference, 2.4; 95% CI, -0.01 to 4.8; P = .052). In the control group, mean scar scores did not vary significantly from baseline at 3 months (mean difference, 1.0; 95% CI, -1.4 to 3.4; P = .96) and at 6 months (mean difference, 0.4; 95% CI, -2.3 to 3.5; P > .99). The needling procedure was not particularly painful, with a mean pain rating of 1.08 of 10. Participants perceived a 41% mean improvement in overall scar appearance on the treated side. No adverse events were reported. CONCLUSIONS AND RELEVANCE: After 3 needling treatments, there was improvement in the appearance of acne scars over time compared with the control group, with minimal pain reported. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00974870.

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