TY - JOUR
T1 - Efficacy of electrical brain stimulation in epilepsy
AU - Widdess-Walsh, Peter
AU - Kellinghaus, Christoph
AU - Geller, Eric
AU - Bsebeck, Frank
AU - Schuele, Stephan
AU - Loddenkemper, Tobias
PY - 2010/9
Y1 - 2010/9
N2 - The brain, in a similar fashion to the heart, is an electrical organ. Antiepileptic medication fails to control seizures in approximately 30% of patients with epilepsy, requires local concentration in the brain following gastrointestinal absorption and has frequent, sometimes serious, side effects. Using electrical brain stimulation therapy to directly modulate neuronal discharges (the origin and basis of seizure activity) holds much promise to reduce seizures in a substantial proportion of patients with refractory epilepsy. Electrical brain stimulation is at the interface of biology, medicine and engineering.
AB - The brain, in a similar fashion to the heart, is an electrical organ. Antiepileptic medication fails to control seizures in approximately 30% of patients with epilepsy, requires local concentration in the brain following gastrointestinal absorption and has frequent, sometimes serious, side effects. Using electrical brain stimulation therapy to directly modulate neuronal discharges (the origin and basis of seizure activity) holds much promise to reduce seizures in a substantial proportion of patients with refractory epilepsy. Electrical brain stimulation is at the interface of biology, medicine and engineering.
KW - closed loop
KW - deep-brain stimulation
KW - epilepsy
KW - local
KW - neuromodulation n neurostimulation
KW - open loop
KW - remote
KW - vagus-nerve stimulation
UR - http://www.scopus.com/inward/record.url?scp=77957154292&partnerID=8YFLogxK
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U2 - 10.2217/thy.10.53
DO - 10.2217/thy.10.53
M3 - Review article
AN - SCOPUS:77957154292
SN - 1475-0708
VL - 7
SP - 481
EP - 496
JO - Therapy
JF - Therapy
IS - 5
ER -