Efficacy of electrical brain stimulation in epilepsy

Peter Widdess-Walsh*, Christoph Kellinghaus, Eric Geller, Frank Bsebeck, Stephan Schuele, Tobias Loddenkemper

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The brain, in a similar fashion to the heart, is an electrical organ. Antiepileptic medication fails to control seizures in approximately 30% of patients with epilepsy, requires local concentration in the brain following gastrointestinal absorption and has frequent, sometimes serious, side effects. Using electrical brain stimulation therapy to directly modulate neuronal discharges (the origin and basis of seizure activity) holds much promise to reduce seizures in a substantial proportion of patients with refractory epilepsy. Electrical brain stimulation is at the interface of biology, medicine and engineering.

Original languageEnglish (US)
Pages (from-to)481-496
Number of pages16
JournalTherapy
Volume7
Issue number5
DOIs
StatePublished - Sep 1 2010

Keywords

  • closed loop
  • deep-brain stimulation
  • epilepsy
  • local
  • neuromodulation n neurostimulation
  • open loop
  • remote
  • vagus-nerve stimulation

ASJC Scopus subject areas

  • Pharmacology (medical)

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