Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia

Jaehyuk Choi, Francine Foss*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Refractory T-lymphoblastic leukemia in adults has a poor prognosis in patients who relapse after allogeneic stem cell transplantation, and relatively few new agents have demonstrated activity. Clofarabine is a novel nucleoside analog that has been associated with significant clinical activity in relapsed pediatric B-ALL. We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalYale Journal of Biology and Medicine
Volume79
Issue number3-4
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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