Abstract
Improving therapy for relapsed/refractory AML remains a challenge. We performed a retrospective analysis of outcomes following decitabine treatment in 34 patients with relapsed/refractory AML (median age, 62; median Charlson comorbidity score, 6). Decitabine, 20 mg/m2 daily, was given in 5- (25%) or 10-day (75%) cycles. Overall response rate (OR) was 30% with 21% complete remission and 9% partial remission rate. Patients with therapy-related myeloid neoplasm (t-MN) and secondary AML had a significantly higher OR compared to those with de novo AML (70 vs. 30%; p =.02). Median overall survival of all patients was 8.5 months. Median survival in patients with t-MN or secondary AML was 12.4 months compared to 8 months in those with de novo AML (p =.20). Fifteen (44%) patients proceeded to hematopoietic stem cell transplant. These data support using 10-day treatment cycles of decitabine in patients with relapsed/refractory AML, particularly for those with secondary or therapy-related AML.
Original language | English (US) |
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Pages (from-to) | 2127-2133 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 58 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2 2017 |
Keywords
- acute myeloid leukemia
- AML
- Decitabine
- refractory AML
- relapsed AML
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research