Efficacy of vinorelbine plus granulocyte colony-stimulation factor for CD34+ hematopoietic progenitor cell mobilization in patients with multiple myeloma

Panagiotis Samaras*, Sarah Pfrommer, Burkhardt Seifert, Ulf Petrausch, Axel Mischo, Adrian Schmidt, Urs Schanz, Gayathri Nair, Mario Bargetzi, Christian Taverna, Roger Stupp, Frank Stenner-Liewen, Christoph Renner

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We aimed to assess the efficacy of vinorelbine plus granulocyte colony-stimulating factor (G-CSF) for chemo-mobilization of CD34+ hematopoietic progenitor cells (HPC) in patients with multiple myeloma and to identify adverse risk factors for successful mobilization. Vinorelbine 35 mg/m2 was administered intravenously on day 1 in an outpatient setting. Filgrastim 5 μg/kg body weight (BW) was given twice daily subcutaneously from day 4 until the end of the collection procedure. Leukapheresis was scheduled to start on day 8 and be performed for a maximum of 3 consecutive days until at least 4× 106 CD34+ cells per kg BW were collected. Overall, 223 patients were mobilized and 221 (99%) patients proceeded to leukapheresis. Three (1.5%) patients required an unscheduled hospitalization after chemo-mobilization because of neutropenic fever and renal failure (n= 1), severe bone pain (n= 1), and abdominal pain with constipation (n= 1). In 211 (95%) patients, the leukaphereses were started as planned at day 8, whereas in 8 (3%) patients the procedure was postponed to day 9 and in 2 (1%) patients to day 10. In the great majority of patients (77%), the predefined amount of HPC could be collected with 1 leukapheresis. Forty-four (20%) patients needed a second leukapheresis, whereas only 6 (3%) patients required a third leukapheresis procedure. The median number of CD34+ cells collected was 6.56× 106 (range, .18 to 25.9× 106) per kg BW at the first day of leukapheresis and 7.65× 106 (range, .18 to 25.9× 106) per kg BW in total. HPC collection was successful in 212 (95%) patients after a maximum of 3 leukaphereses. Patient age (P= .02) and prior exposition to lenalidomide (P < .001) were independent risk factors for a lower HPC amount collected in multiple regression analysis. Vinorelbine plus G-CSF enables a very reliable prediction of the timing of leukapheresis and results in successful HPC collection in 95% of the patients.

Original languageEnglish (US)
Pages (from-to)74-80
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Chemo-mobilization
  • Hematopoietic progenitor cell mobilization
  • Lenalidomide
  • Multiple myeloma
  • Vinorelbine

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Efficacy of vinorelbine plus granulocyte colony-stimulation factor for CD34<sup>+</sup> hematopoietic progenitor cell mobilization in patients with multiple myeloma'. Together they form a unique fingerprint.

Cite this