Abstract
The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1730-1733 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 139 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 8 2017 |
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ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
Cite this
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Efficient charge transport via DNA G-quadruplexes. / Thazhathveetil, Arun K.; Harris, Michelle A.; Young, Ryan Michael; Wasielewski, Michael R; Lewis, Frederick D.
In: Journal of the American Chemical Society, Vol. 139, No. 5, 08.02.2017, p. 1730-1733.Research output: Contribution to journal › Article
TY - JOUR
T1 - Efficient charge transport via DNA G-quadruplexes
AU - Thazhathveetil, Arun K.
AU - Harris, Michelle A.
AU - Young, Ryan Michael
AU - Wasielewski, Michael R
AU - Lewis, Frederick D
PY - 2017/2/8
Y1 - 2017/2/8
N2 - The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.
AB - The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.
UR - http://www.scopus.com/inward/record.url?scp=85011876488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011876488&partnerID=8YFLogxK
U2 - 10.1021/jacs.6b10265
DO - 10.1021/jacs.6b10265
M3 - Article
C2 - 28094928
AN - SCOPUS:85011876488
VL - 139
SP - 1730
EP - 1733
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 5
ER -