Efficient charge transport via DNA G-quadruplexes

Arun K. Thazhathveetil, Michelle A. Harris, Ryan Michael Young, Michael R Wasielewski*, Frederick D Lewis

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.

Original languageEnglish (US)
Pages (from-to)1730-1733
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number5
DOIs
StatePublished - Feb 8 2017

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G-Quadruplexes
Charge transfer
DNA
Hole traps
Absorption spectroscopy
Base Pairing
Spectrum Analysis
Ions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.",
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Efficient charge transport via DNA G-quadruplexes. / Thazhathveetil, Arun K.; Harris, Michelle A.; Young, Ryan Michael; Wasielewski, Michael R; Lewis, Frederick D.

In: Journal of the American Chemical Society, Vol. 139, No. 5, 08.02.2017, p. 1730-1733.

Research output: Contribution to journalArticle

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AU - Young, Ryan Michael

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AU - Lewis, Frederick D

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