Efficient charge transport via DNA G-quadruplexes

Arun K. Thazhathveetil; Michelle A. Harris; Ryan Michael Young; Michael R Wasielewski; Frederick D Lewis

doi:10.1021/jacs.6b10265

Efficient charge transport via DNA G-quadruplexes

Arun K. Thazhathveetil, Michelle A. Harris, Ryan Michael Young, Michael R Wasielewski^*, Frederick D Lewis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the S^a-•/Sd^+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.

Original language	English (US)
Pages (from-to)	1730-1733
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	139
Issue number	5
DOIs	https://doi.org/10.1021/jacs.6b10265
State	Published - Feb 8 2017

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.",

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AU - Lewis, Frederick D

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