Efficient method for volumetric assessment of peak blood flow velocity using 4D flow MRI

Michael J. Rose*, Kelly Jarvis, Varun Chowdhary, Alex J Barker, Bradley D. Allen, Joshua D Robinson, Michael Markl, Cynthia K Rigsby, Susanne Schnell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Purpose: To test the feasibility and effectiveness of using maximum intensity plots (MIPs) based on 4D flow magnetic resonance imaging (MRI) velocity data to assess systolic peak velocities in a cohort of bicuspid aortic valve (BAV) patients. Materials and Methods: 4D flow MRI at 1.5T was performed on 51 BAV patients. MIPs were generated from the 4D flow MRI velocity data and used by two users to determine peak velocities in three regions of interest (ROIs): ascending aorta (AAo), aortic arch, and descending aorta. 4D flow MRI peak velocities in the AAo were compared to peak velocities recorded by 2D phase contrast MRI (2D PCMRI) in a subcohort of 36 patients and by Doppler echocardiography in a subcohort of 34 patients. 4D flow MRI peak velocities recorded by each observer were compared for all ROIs to test for interobserver variability. Results: 4D flow MRI recorded significantly higher velocities compared to 2D PCMRI (2.04 ± 0.71 m/s vs. 1.69 ± 0.79 m/s, 17.2% difference, P < 0.001) and similar velocities compared to Doppler echocardiography. There was excellent agreement between the observers, with a mean difference of 0.005 m/s and an intraclass correlation coefficient of 0.98. Conclusion: 4D flow MRI velocity MIPs allow for efficient measurement of peak velocities in BAV patients with higher accuracy than 2D PCMRI and similar accuracy to Doppler echocardiography. J. Magn. Reson. Imaging 2016;44:1673–1682.

Original languageEnglish (US)
Pages (from-to)1673-1682
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 1 2016


  • 4D flow
  • MRI
  • bicuspid aortic valve
  • pediatric
  • phase contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Efficient method for volumetric assessment of peak blood flow velocity using 4D flow MRI'. Together they form a unique fingerprint.

Cite this