Efficient synthesis of acylsilanes using morpholine amides

Christopher T. Clark, Benjamin C. Milgram, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


(Chemical Equation Presented) A general synthesis of acylsilanes from the corresponding morpholine amides and silyllithium species is described. The use of morpholine amides is economical and prevents over-addition by the silyl nucleophile. The procedure cleanly affords acylsilanes in good yields and circumvents the use of stoichiometric copper(I) cyanide typically employed to synthesize these compounds from acid chlorides.

Original languageEnglish (US)
Pages (from-to)3977-3980
Number of pages4
JournalOrganic Letters
Issue number22
StatePublished - Oct 28 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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