Efficient synthesis of immolative carbamate dendrimer with olefinic periphery

Jeong Kyu Lee, Young Woong Suh, Mayfair C. Kung, Christopher M. Downing, Harold H. Kung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An efficient synthetic strategy for immolative carbamate dendrons and dendrimers is described that requires no protection/deprotection in the convergent growth step. 1,3-Diamino-2-propanol was used as AB2 building block and 4-nitrophenyl chloroformate as carbamate forming reagent. The method was demonstrated with a G3-dendron. A combination of convergent and divergent growth method was used to couple G2-dendrons to a G2-core or G3-dendrons to a tetrahedral G1-core with amine functional groups to form a spherical carbamate dendrimer (G4) possessing an olefinic periphery.

Original languageEnglish (US)
Pages (from-to)4919-4923
Number of pages5
JournalTetrahedron Letters
Issue number28
StatePublished - Jul 9 2007


  • 1,3-Diamino-2-propanol
  • 4-Nitrophenyl chloroformate
  • Carbamate dendron
  • Immolative dendrimer

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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