Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Shashank Gupta; Keira A. Cohen; Kathryn Winglee; Mamoudou Maiga; Bassirou Diarra; William R. Bishai

doi:10.1128/AAC.01462-13

Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Shashank Gupta, Keira A. Cohen, Kathryn Winglee, Mamoudou Maiga, Bassirou Diarra, William R. Bishai^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

Original language	English (US)
Pages (from-to)	574-576
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01462-13
State	Published - Jan 2014

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ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01462-13

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AU - Diarra, Bassirou

AU - Bishai, William R.

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AB - Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

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Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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