Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Shashank Gupta, Keira A. Cohen, Kathryn Winglee, Mamoudou Maiga, Bassirou Diarra, William R. Bishai*

*Corresponding author for this work

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

Original languageEnglish (US)
Pages (from-to)574-576
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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