EIF4G1 mutations do not cause Parkinson's disease

Noah Nichols; Jose M. Bras; Dena G. Hernandez; Iris E. Jansen; Suzanne Lesage; Steven Lubbe; Andrew B. Singleton; Parkinson's Disease Genomics Consortium International Parkinson's Disease Genomics Consortium

doi:10.1016/j.neurobiolaging.2015.04.017

EIF4G1 mutations do not cause Parkinson's disease

Noah Nichols, Jose M. Bras, Dena G. Hernandez, Iris E. Jansen, Suzanne Lesage, Steven Lubbe, Andrew B. Singleton^*, Parkinson's Disease Genomics Consortium International Parkinson's Disease Genomics Consortium

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

Original language	English (US)
Pages (from-to)	2444.e1-2444.e4
Journal	Neurobiology of Aging
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.04.017
State	Published - 2015

Keywords

EIF4G1
Genetics
Mutation
Parkinson's disease

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Aging
General Neuroscience
Developmental Biology

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10.1016/j.neurobiolaging.2015.04.017

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title = "EIF4G1 mutations do not cause Parkinson's disease",

abstract = "EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.",

keywords = "EIF4G1, Genetics, Mutation, Parkinson's disease",

author = "Noah Nichols and Bras, {Jose M.} and Hernandez, {Dena G.} and Jansen, {Iris E.} and Suzanne Lesage and Steven Lubbe and Singleton, {Andrew B.} and {International Parkinson's Disease Genomics Consortium}, {Parkinson's Disease Genomics Consortium}",

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T1 - EIF4G1 mutations do not cause Parkinson's disease

AU - Nichols, Noah

AU - Bras, Jose M.

AU - Hernandez, Dena G.

AU - Jansen, Iris E.

AU - Lesage, Suzanne

AU - Lubbe, Steven

AU - Singleton, Andrew B.

AU - International Parkinson's Disease Genomics Consortium, Parkinson's Disease Genomics Consortium

PY - 2015

Y1 - 2015

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AB - EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

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KW - Genetics

KW - Mutation

KW - Parkinson's disease

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EIF4G1 mutations do not cause Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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