EIF4G1 mutations do not cause Parkinson's disease

Noah Nichols, Jose M. Bras, Dena G. Hernandez, Iris E. Jansen, Suzanne Lesage, Steven Lubbe, Andrew B. Singleton*, Parkinson's Disease Genomics Consortium International Parkinson's Disease Genomics Consortium

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

Original languageEnglish (US)
Pages (from-to)2444.e1-2444.e4
JournalNeurobiology of Aging
Volume36
Issue number8
DOIs
StatePublished - 2015

Keywords

  • EIF4G1
  • Genetics
  • Mutation
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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