Eight unexpected cases of vancomycin associated acute kidney injury with contemporary dosing

J. Nicholas O'Donnell, Cybele Ghossein, Nathaniel J. Rhodes, Jessica Peng, Tina Lertharakul, C. Kim Pham, Marc H. Scheetz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Vancomycin is one of the most commonly utilized antibiotics in US hospitals. It remains the drug of choice for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. For many of these deep-seated infections, guidelines recommend achieving troughs of 15–20 mg/L for treatment efficacy. At our institution we observed a number of cases of presumed vancomycin-induced acute tubular necrosis clinically diagnosed by the nephrology service. We report eight cases of presumed vancomycin-induced acute tubular necrosis, three of which required hemodialysis before resolution of nephrotoxicity. Only three of the eight patients received nephrotoxins prior to development of nephrotoxicity. All eight patients ultimately recovered renal function following discontinuation.

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume23
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • Acute tubular necrosis
  • Hemodialysis
  • Kidney injury
  • Vancomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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