Eight unexpected cases of vancomycin associated acute kidney injury with contemporary dosing

J. Nicholas O'Donnell; Cybele Ghossein; Nathaniel J. Rhodes; Jessica Peng; Tina Lertharakul; C. Kim Pham; Marc H. Scheetz

doi:10.1016/j.jiac.2016.12.011

Eight unexpected cases of vancomycin associated acute kidney injury with contemporary dosing

J. Nicholas O'Donnell, Cybele Ghossein, Nathaniel J. Rhodes, Jessica Peng, Tina Lertharakul, C. Kim Pham, Marc H. Scheetz^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Vancomycin is one of the most commonly utilized antibiotics in US hospitals. It remains the drug of choice for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. For many of these deep-seated infections, guidelines recommend achieving troughs of 15–20 mg/L for treatment efficacy. At our institution we observed a number of cases of presumed vancomycin-induced acute tubular necrosis clinically diagnosed by the nephrology service. We report eight cases of presumed vancomycin-induced acute tubular necrosis, three of which required hemodialysis before resolution of nephrotoxicity. Only three of the eight patients received nephrotoxins prior to development of nephrotoxicity. All eight patients ultimately recovered renal function following discontinuation.

Original language	English (US)
Pages (from-to)	326-332
Number of pages	7
Journal	Journal of Infection and Chemotherapy
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.jiac.2016.12.011
State	Published - May 1 2017

Funding

Research reported in this publication was supported by National Institute of Allergy and Infectious Diseases under award number R15-AI105742. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Keywords

Acute tubular necrosis
Hemodialysis
Kidney injury
Vancomycin

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2016.12.011

Cite this

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abstract = "Vancomycin is one of the most commonly utilized antibiotics in US hospitals. It remains the drug of choice for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. For many of these deep-seated infections, guidelines recommend achieving troughs of 15–20 mg/L for treatment efficacy. At our institution we observed a number of cases of presumed vancomycin-induced acute tubular necrosis clinically diagnosed by the nephrology service. We report eight cases of presumed vancomycin-induced acute tubular necrosis, three of which required hemodialysis before resolution of nephrotoxicity. Only three of the eight patients received nephrotoxins prior to development of nephrotoxicity. All eight patients ultimately recovered renal function following discontinuation.",

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AU - Rhodes, Nathaniel J.

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AU - Lertharakul, Tina

AU - Pham, C. Kim

AU - Scheetz, Marc H.

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Eight unexpected cases of vancomycin associated acute kidney injury with contemporary dosing

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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