Einteilung des Schweregrads der akuten Pankreatitis: Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013

Translated title of the contribution: Determinant-based classification of acute pancreatitis severity: International multidisciplinary classification of acute pancreatitis severity: The 2013 German Edition

E. Patchen Dellinger, Christopher E. Forsmark, Peter Layer, Philippe Levy, Enrique Maraví-Poma, Maxim S. Petrov*, Tooru Shimosegawa, Ajith K. Siriwardena, Generoso Uomo, David C. Whitcomb, John A. Windsor, M. Abu Hilal, F. M. Abu-Zidan, J. M. Acosta, A. P. Ainsworth, M. Aizcorbe Garralda, H. Alagozlu, S. J. Al'aref, E. Albeniz Arbizu, A. AlhajeriI. C. Almeida, J. L. Almeida, H. Amano, B. J. Ammori, R. Andersson, A. Andrén-Sandberg, J. C. Ardengh, A. S. Arroyo-Sanchez, M. Arvanitakis, S. W. Ashley, G. Aygencel, W. A. Ayoub, J. Baillie, M. Bala, C. G. Ball, T. H. Baron, S. G. Barreto, M. Basaranoglu, H. G. Beger, V. Bernal Monterde, N. Bharwani, D. K. Bhasin, J. J. Bong, G. Botoi, T. Bruennler, E. Cairoli, C. R. Carter, D. Cernea, S. T. Chari, R. M. Charnley, S. Chooklin, D. Cochior, C. Col, D. L. Conwell, M. I. Correia, Z. Dambrauskas, K. Darvas, T. De Campos, G. G. De Casasola, J. J. De Waele, M. Del Chiaro, G. Delle Fave, E. P. Dellinger, E. De-Madaria, P. Di Sebastiano, T. G. Diuzheva, A. Duarte-Rojo, P. J. Fagenholz, G. Farkas, A. Farre Viladrich, C. Fernandezdel Castillo, C. E. Forsmark, H. Friess, J. L. Frossard, V. Gandhi, T. B. Gardner, B. Gloor, M. Gluk, V. R. Goltsov, J. Guevara-Campos, A. A. Gumbs, T. Hackert, G. Hauser, K. D. Horvath, T. J. Howard, H. Igarashi, O. Ioannidis, S. Jaber, F. E. James, R. K. Jha, D. Juneja, T. Kamisawa, P. Kandasami, M. Kantarcioglu, V. K. Kapoor, T. Karakan, E. Kaya, A. Khaliq, S. Kiriyama, R. Kochhar, G. N. Konstantinou, M. L. Kylänpää, P. G. Lankisch, C. Laplaza Santos, J. Lata, P. Layer, A. Leppäniemi, P. Levy, A. Lopez, V. López Camps, L. A. Lujano-Nicolas, H. Lund, D. Lytras, L. Macaya Redin, M. C. Machado, M. A. Macias Rodriguez, O. Mann, E. Maravi-Poma, M. Marincas, S. Marwah, E. Mas, A. S. Matheus, R. Meier, D. Mennecier, P. Mentula, A. Mifkovic, R. Mofidi, D. J. Mole, G. Morris-Stiff, J. Mossner, M. A. Muftuoglu, M. A. Munsell, A. B. Nathens, V. Neri, C. Nöjgaard, I. Nordback, C. Ocampo, A. Oláh, J. Olejnik, D. A. O'Reilly, A. Oria, J. Panek, G. I. Papachristou, D. Parekh, R. W. Parks, C. Passaglia, C. B. Pearce, D. Pellegrini, M. Perez-Mateo, M. S. Petrov*, V. Pettila, R. Pezzilli, C. S. Pitchumoni, S. Pongprasobchai, I. Poves Prim, P. Puolakkainen, G. Pupelis, D. V. Radenkovic, S. H. Rahman, E. Regidor Sanz, A. Repiso, L. Rodrigo, A. Rosseland, G. Rydzewska, J. A. Sánchez-Izquierdo Riera, T. J. Savides, M. Scaglione, A. Serrablo, E. Servin-Torres, I. Sethu, O. Sezgin, M. Shankar-Hari, T. Shimosegawa, M. V. Singer, S. K. Sinha, A. K. Siriwardena, T. Sjoberg Bexelius, J. R. Skipworth, F. G. Soriano, R. Sotoudehmanesh, B. W. Spanier, B. Stabuc, C. Stroescu, Z. Szentkereszty, T. Takacs, T. Takada, K. Takeda, Y. Takeyama, W. Tang, K. Tanjoh, P. R. Tarnasky, N. Teich, J. M. Tellado, S. Tenner, A. Thomson, M. Tireli, Z. Tong, C. Triantopoulou, G. Uomo, M. C. Uy, E. J. Van Geenen, A. Velasco Guardado, N. Vettoretto, C. M. Vollmer, K. Wada, A. L. Warshaw, A. A. Weinbroum, D. C. Whitcomb, J. S. Wilson, M. Wittau, B. U. Wu, A. P. Wysocki, E. Yan Quiros, T. Yasuda, C. Yu, E. Zerem, X. Zhou, F. Zubia Olazcoaga, N. J. Zyromski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To develop a new classification of acute pancreatitis severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Background: The Atlanta definitions of acute pancreatitis severity are ingrained in the lexicon of pancreatologists but suboptimal because these definitions are based on empiric description of occurrences that are merely associated with severity. Methods: A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroen-terologists, internists, intensivists, and radiologists who are currently active in clinical research on acute pancreatitis. The invitation was not limited to members of certain associations or residents of certain countries. A global Web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Result: The new classification of severity is based on the actual local and systemic determinants of severity, rather than description of events that are correlated with severity. The local determinant relates to whether there is (peri)pancreatic necrosis or not, and if present, whether it is sterile or infected. The systemic determinant relates to whether there is organ failure or not, and if present, whether it is transient or persistent. The presence of one determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure have a greater effect on severity than either determinant alone. The derivation of a classification based on the above principles results in 4 categories of severity-mild, moderate, severe, and critical. Conclusions: This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of acute pancreatitis in clinical practice and research. This ensures that the determinant-based classification can be used in a uniform manner throughout the world.

Translated title of the contributionDeterminant-based classification of acute pancreatitis severity: International multidisciplinary classification of acute pancreatitis severity: The 2013 German Edition
Original languageGerman
Pages (from-to)544-550
Number of pages7
JournalZeitschrift fur Gastroenterologie
Issue number6
StatePublished - 2013


  • acute pancreatitis
  • classification
  • definition
  • organ failure
  • pancreatic infectious complications
  • pancreatic necrosis
  • peripancreatic necrosis
  • severity

ASJC Scopus subject areas

  • Gastroenterology


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