Elacytarabine lipid vector technology overcoming drug resistance in acute myeloid leukemia

Aine Carol Burke*, Frank James Giles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Introduction: Ara-C (cytarabine arabinoside) is a deoxycytidine analog that has an established role in the treatment of hematologic malignancies, especially acute myeloid leukemia. Resistance to ara-C occurs and impacts negatively on survival. To combat this, an elaidic acid ester of ara-C, called elacytarabine, has been developed. This novel agent is highly efficacious in cells with demonstrable resistance to the parent agent, including in solid tumor xenografts. Areas covered: The mechanisms that account for the increased clinical activity of elacytarabine are discussed, including its ability to bypass the specialized transmembrane nucleoside transport system on which ara-C depends, its prolonged retention within the cell and its alternative effect on the cell cycle. The development and synthesis and pharmacokinetics are outlined, with emphasis on lipid vector technology. Ten clinical trials involving elacytarabine, either as monotherapy or part of a combination regimen, have been carried out in both solid tumor and hematologic malignancies. The efficacy and side effect profile results are summarized. Expert opinion: Clinical trials in patients with hematological malignancies are reporting very encouraging efficacy results with an acceptable side effect profile. Elacytarabine has the potential to play an important role in the treatment of multiple malignancies in the future and results from an ongoing Phase III clinical trial are eagerly awaited.

Original languageEnglish (US)
Pages (from-to)1707-1715
Number of pages9
JournalExpert Opinion on Investigational Drugs
Volume20
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • Acute myeloid leukemia
  • Ara-C
  • CP-4055
  • Cytarabine
  • Drug development
  • Elacytarabine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Elacytarabine lipid vector technology overcoming drug resistance in acute myeloid leukemia'. Together they form a unique fingerprint.

Cite this