Elastic phase response of silica nanoparticles buried in soft matter

Laurene Tetard*, Ali Passian, Rachel M. Lynch, Brynn H. Voy, Gajendra Shekhawat, Vinayak Dravid, Thomas Thundat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Tracking the uptake of nanomaterials by living cells is an important component in assessing both potential toxicity and in designing future materials for use in vivo. We show that the difference in the local elasticity at the site of silica (SiO2) nanoparticles confined within a macrophage enables functional ultrasonic interactions. By elastically exciting the cell, a phase perturbation caused by the buried SiO2 nanoparticles was detected and used to map the subsurface populations of nanoparticles. Localization and mapping of stiff chemically synthesized silica nanoparticles within the cellular structures of a macrophage are important in basic as well as applied studies.

Original languageEnglish (US)
Article number133113
JournalApplied Physics Letters
Issue number13
StatePublished - 2008

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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