Electrical and optical co-stimulation in the deaf white cat

Zhiping Cao; Yingyue Xu; Xiaodong Tan; Naofumi Suematsu; Alan Robinson; Claus Peter Richter

doi:10.1117/12.2291839

Electrical and optical co-stimulation in the deaf white cat

Zhiping Cao, Yingyue Xu, Xiaodong Tan, Naofumi Suematsu, Alan Robinson, Claus Peter Richter

Otolaryngology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Spatial selectivity of neural stimulation with photons, such as infrared neural stimulation (INS) is higher than the selectivity obtained with electrical stimulation. To obtain more independent channels for stimulation in neural prostheses, INS may be implemented to better restore the fidelity of the damaged neural system. However, irradiation with infrared light also bares the risk of heat accumulation in the target tissue with subsequent neural damage. Lowering the threshold for stimulation could reduce the amount of heat delivered to the tissue and the risk for subsequent tissue damage. It has been shown in the rat sciatic nerve that simultaneous irradiation with infrared light and the delivery of biphasic sub-threshold electrical pulses can reduce the threshold for INS [1]. In this study, deaf white cats have been used to test whether opto-electrical co-stimulation can reduce the stimulation threshold for INS in the auditory system too. The cochleae of the deaf white cats have largely reduced spiral ganglion neuron counts and significant degeneration of the organ of Corti and do not respond to acoustic stimuli. Combined electrical and optical stimulation was used to demonstrate that simultaneous stimulation with infrared light and biphasic electrical pulses can reduce the threshold for stimulation.

Original language	English (US)
Title of host publication	Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018
Editors	Max J. Witjes, Brian J. F. Wong, Justus F. Ilgner
Publisher	SPIE
ISBN (Electronic)	9781510614239
DOIs	https://doi.org/10.1117/12.2291839
State	Published - 2018
Event	Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018 - San Francisco, United States Duration: Jan 27 2018 → Jan 28 2018

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10469
ISSN (Print)	1605-7422

Other

Other	Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018
Country/Territory	United States
City	San Francisco
Period	1/27/18 → 1/28/18

Funding

This project has been funded with federal funds from the NIDCD, R01 DC011855 and by the Hugh Knowles Center for Clinical and Basic Science in Hearing and its Disorders.

Keywords

co-stimulation
cochlea
hearing
hybrid stimulation
infrared neural stimulation
laser

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2291839

Cite this

Cao, Z., Xu, Y., Tan, X., Suematsu, N., Robinson, A., & Richter, C. P. (2018). Electrical and optical co-stimulation in the deaf white cat. In M. J. Witjes, B. J. F. Wong, & J. F. Ilgner (Eds.), Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018 Article 104690U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10469). SPIE. https://doi.org/10.1117/12.2291839

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title = "Electrical and optical co-stimulation in the deaf white cat",

abstract = "Spatial selectivity of neural stimulation with photons, such as infrared neural stimulation (INS) is higher than the selectivity obtained with electrical stimulation. To obtain more independent channels for stimulation in neural prostheses, INS may be implemented to better restore the fidelity of the damaged neural system. However, irradiation with infrared light also bares the risk of heat accumulation in the target tissue with subsequent neural damage. Lowering the threshold for stimulation could reduce the amount of heat delivered to the tissue and the risk for subsequent tissue damage. It has been shown in the rat sciatic nerve that simultaneous irradiation with infrared light and the delivery of biphasic sub-threshold electrical pulses can reduce the threshold for INS [1]. In this study, deaf white cats have been used to test whether opto-electrical co-stimulation can reduce the stimulation threshold for INS in the auditory system too. The cochleae of the deaf white cats have largely reduced spiral ganglion neuron counts and significant degeneration of the organ of Corti and do not respond to acoustic stimuli. Combined electrical and optical stimulation was used to demonstrate that simultaneous stimulation with infrared light and biphasic electrical pulses can reduce the threshold for stimulation.",

keywords = "co-stimulation, cochlea, hearing, hybrid stimulation, infrared neural stimulation, laser",

author = "Zhiping Cao and Yingyue Xu and Xiaodong Tan and Naofumi Suematsu and Alan Robinson and Richter, {Claus Peter}",

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Cao, Z, Xu, Y, Tan, X, Suematsu, N, Robinson, A & Richter, CP 2018, Electrical and optical co-stimulation in the deaf white cat. in MJ Witjes, BJF Wong & JF Ilgner (eds), Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018., 104690U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10469, SPIE, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018, San Francisco, United States, 1/27/18. https://doi.org/10.1117/12.2291839

Electrical and optical co-stimulation in the deaf white cat. / Cao, Zhiping; Xu, Yingyue; Tan, Xiaodong et al.
Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018. ed. / Max J. Witjes; Brian J. F. Wong; Justus F. Ilgner. SPIE, 2018. 104690U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10469).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Electrical and optical co-stimulation in the deaf white cat

AU - Cao, Zhiping

AU - Xu, Yingyue

AU - Tan, Xiaodong

AU - Suematsu, Naofumi

AU - Robinson, Alan

AU - Richter, Claus Peter

N1 - Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2018

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N2 - Spatial selectivity of neural stimulation with photons, such as infrared neural stimulation (INS) is higher than the selectivity obtained with electrical stimulation. To obtain more independent channels for stimulation in neural prostheses, INS may be implemented to better restore the fidelity of the damaged neural system. However, irradiation with infrared light also bares the risk of heat accumulation in the target tissue with subsequent neural damage. Lowering the threshold for stimulation could reduce the amount of heat delivered to the tissue and the risk for subsequent tissue damage. It has been shown in the rat sciatic nerve that simultaneous irradiation with infrared light and the delivery of biphasic sub-threshold electrical pulses can reduce the threshold for INS [1]. In this study, deaf white cats have been used to test whether opto-electrical co-stimulation can reduce the stimulation threshold for INS in the auditory system too. The cochleae of the deaf white cats have largely reduced spiral ganglion neuron counts and significant degeneration of the organ of Corti and do not respond to acoustic stimuli. Combined electrical and optical stimulation was used to demonstrate that simultaneous stimulation with infrared light and biphasic electrical pulses can reduce the threshold for stimulation.

AB - Spatial selectivity of neural stimulation with photons, such as infrared neural stimulation (INS) is higher than the selectivity obtained with electrical stimulation. To obtain more independent channels for stimulation in neural prostheses, INS may be implemented to better restore the fidelity of the damaged neural system. However, irradiation with infrared light also bares the risk of heat accumulation in the target tissue with subsequent neural damage. Lowering the threshold for stimulation could reduce the amount of heat delivered to the tissue and the risk for subsequent tissue damage. It has been shown in the rat sciatic nerve that simultaneous irradiation with infrared light and the delivery of biphasic sub-threshold electrical pulses can reduce the threshold for INS [1]. In this study, deaf white cats have been used to test whether opto-electrical co-stimulation can reduce the stimulation threshold for INS in the auditory system too. The cochleae of the deaf white cats have largely reduced spiral ganglion neuron counts and significant degeneration of the organ of Corti and do not respond to acoustic stimuli. Combined electrical and optical stimulation was used to demonstrate that simultaneous stimulation with infrared light and biphasic electrical pulses can reduce the threshold for stimulation.

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BT - Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018

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Cao Z, Xu Y, Tan X, Suematsu N, Robinson A, Richter CP. Electrical and optical co-stimulation in the deaf white cat. In Witjes MJ, Wong BJF, Ilgner JF, editors, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018. SPIE. 2018. 104690U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2291839

Electrical and optical co-stimulation in the deaf white cat

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