Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate

D. Michael Ackermann, Christian Ethier, Emily L. Foldes, Emily R. Oby, Dustin Tyler, Matt Bauman, Niloy Bhadra, Lee Miller, Kevin L. Kilgore

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalMuscle and Nerve
Volume43
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Conduction block
  • High-frequency alternating current (HFAC)
  • Large diameter
  • Peripheral nerve
  • Primate

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Michael Ackermann, D., Ethier, C., Foldes, E. L., Oby, E. R., Tyler, D., Bauman, M., Bhadra, N., Miller, L., & Kilgore, K. L. (2011). Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate. Muscle and Nerve, 43(6), 897-899. https://doi.org/10.1002/mus.22037