Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate

D. Michael Ackermann; Christian Ethier; Emily L. Foldes; Emily R. Oby; Dustin Tyler; Matt Bauman; Niloy Bhadra; Lee Miller; Kevin L. Kilgore

doi:10.1002/mus.22037

Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate

D. Michael Ackermann, Christian Ethier, Emily L. Foldes, Emily R. Oby, Dustin Tyler, Matt Bauman, Niloy Bhadra, Lee Miller, Kevin L. Kilgore

Neuroscience

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

Original language	English (US)
Pages (from-to)	897-899
Number of pages	3
Journal	Muscle and Nerve
Volume	43
Issue number	6
DOIs	https://doi.org/10.1002/mus.22037
State	Published - Jun 2011

Keywords

Conduction block
High-frequency alternating current (HFAC)
Large diameter
Peripheral nerve
Primate

ASJC Scopus subject areas

Clinical Neurology
Physiology (medical)
Cellular and Molecular Neuroscience
Physiology

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10.1002/mus.22037

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title = "Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate",

abstract = "Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.",

keywords = "Conduction block, High-frequency alternating current (HFAC), Large diameter, Peripheral nerve, Primate",

author = "{Michael Ackermann}, D. and Christian Ethier and Foldes, {Emily L.} and Oby, {Emily R.} and Dustin Tyler and Matt Bauman and Niloy Bhadra and Lee Miller and Kilgore, {Kevin L.}",

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AU - Michael Ackermann, D.

AU - Ethier, Christian

AU - Foldes, Emily L.

AU - Oby, Emily R.

AU - Tyler, Dustin

AU - Bauman, Matt

AU - Bhadra, Niloy

AU - Miller, Lee

AU - Kilgore, Kevin L.

PY - 2011/6

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N2 - Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

AB - Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

KW - Conduction block

KW - High-frequency alternating current (HFAC)

KW - Large diameter

KW - Peripheral nerve

KW - Primate

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Electrical conduction block in large nerves: Highfrequency current delivery in the nonhuman primate

Abstract

Keywords

ASJC Scopus subject areas

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