Electrical coupling between mammalian cones

Steven H DeVries, Xiaofeng Qi, Robert Smith, Walter Makous, Peter Sterling*

*Corresponding author for this work

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Background: Cone photoreceptors are noisy because of random fluctuations of photon absorption, signaling molecules, and ion channels. However, each cone's noise is independent of the others, whereas their signals are partially shared. Therefore, electrically coupling the synaptic terminals prior to forward transmission and subsequent nonlinear processing can appreciably reduce noise relative to the signal. This signal-processing strategy has been demonstrated in lower vertebrates with rather coarse vision, but its occurrence in mammals with fine acuity has been doubted (even though gap junctions are present) because coupling would blur the neural image. Results: In ground squirrel retina, whose triangular cone lattice resembles the human fovea, paired electrical recordings from adjacent cones demonstrated electrical coupling with an average conductance of approximately 320 pS. Blur caused by this degree of coupling had a space constant of approximately 0.5 cone diameters. Psychophysical measurements employing laser interferometry to bypass the eye's optics suggest that human foveal cones experience a similar degree of neural blur and that it is invariant with light intensity. This neural blur is narrower than the eye's optical blur, and we calculate that it should improve the signal-to-noise ratio at the cone terminal by about 77%. Conclusions: We conclude that the gap junctions observed between mammalian cones, including those in the human fovea, represent genuine electrical coupling. Because the space constant of the resulting neural blur is less than that of the optical blur, the signal-to-noise ratio can be markedly improved before the nonlinear stages with little compromise to visual acuity.

Original languageEnglish (US)
Pages (from-to)1900-1907
Number of pages8
JournalCurrent Biology
Volume12
Issue number22
DOIs
StatePublished - Nov 19 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    DeVries, S. H., Qi, X., Smith, R., Makous, W., & Sterling, P. (2002). Electrical coupling between mammalian cones. Current Biology, 12(22), 1900-1907. https://doi.org/10.1016/S0960-9822(02)01261-7