Electrical self-stimulation of dentate gyrus granule cells

Timothy J. Collier, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Male albino rats implanted with a chronic stimulating electrode electrophysiologically guided into the granule cell layer of the dorsal dentate gyrus were tested in a self-stimulation paradigm. It was found that subjects self-administer electrical stimulation to the granule cells at low, steady rates. Consistent with the presence of opioid-like immunoreactivity in the granule cell mossy fiber pathway, intraperitoneal injection of the opiate antagonist naloxone diminishes granule cell self-stimulation in a dose-related fashion. The results suggest that a granule cell opioid synapse participates in expression of reward at this site.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalBehavioral and Neural Biology
Issue number1
StatePublished - Sep 1984

ASJC Scopus subject areas

  • Physiology


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