Electrical self-stimulation of dentate gyrus granule cells

Timothy J. Collier; Aryeh Routtenberg

doi:10.1016/S0163-1047(84)90472-2

Electrical self-stimulation of dentate gyrus granule cells

Timothy J. Collier, Aryeh Routtenberg^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Male albino rats implanted with a chronic stimulating electrode electrophysiologically guided into the granule cell layer of the dorsal dentate gyrus were tested in a self-stimulation paradigm. It was found that subjects self-administer electrical stimulation to the granule cells at low, steady rates. Consistent with the presence of opioid-like immunoreactivity in the granule cell mossy fiber pathway, intraperitoneal injection of the opiate antagonist naloxone diminishes granule cell self-stimulation in a dose-related fashion. The results suggest that a granule cell opioid synapse participates in expression of reward at this site.

Original language	English (US)
Pages (from-to)	85-90
Number of pages	6
Journal	Behavioral and Neural Biology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0163-1047(84)90472-2
State	Published - Sep 1984

ASJC Scopus subject areas

Physiology

Access to Document

10.1016/S0163-1047(84)90472-2

Cite this

@article{36719b9896ab4d94a7073e8c1fb70994,

title = "Electrical self-stimulation of dentate gyrus granule cells",

abstract = "Male albino rats implanted with a chronic stimulating electrode electrophysiologically guided into the granule cell layer of the dorsal dentate gyrus were tested in a self-stimulation paradigm. It was found that subjects self-administer electrical stimulation to the granule cells at low, steady rates. Consistent with the presence of opioid-like immunoreactivity in the granule cell mossy fiber pathway, intraperitoneal injection of the opiate antagonist naloxone diminishes granule cell self-stimulation in a dose-related fashion. The results suggest that a granule cell opioid synapse participates in expression of reward at this site.",

author = "Collier, {Timothy J.} and Aryeh Routtenberg",

note = "Funding Information: 2 The authors thank J. Miller, L. Cahill, and D. Barnes for expert technical assistance. Research supported by predoctoral fellowship MH 16097 to T.J.C. and NIMH 25281 to A.R. Send requests for reprints to A. Routtenberg.",

year = "1984",

month = sep,

doi = "10.1016/S0163-1047(84)90472-2",

language = "English (US)",

volume = "42",

pages = "85--90",

journal = "Behavioral and Neural Biology",

issn = "0163-1047",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Electrical self-stimulation of dentate gyrus granule cells

AU - Collier, Timothy J.

AU - Routtenberg, Aryeh

N1 - Funding Information: 2 The authors thank J. Miller, L. Cahill, and D. Barnes for expert technical assistance. Research supported by predoctoral fellowship MH 16097 to T.J.C. and NIMH 25281 to A.R. Send requests for reprints to A. Routtenberg.

PY - 1984/9

Y1 - 1984/9

N2 - Male albino rats implanted with a chronic stimulating electrode electrophysiologically guided into the granule cell layer of the dorsal dentate gyrus were tested in a self-stimulation paradigm. It was found that subjects self-administer electrical stimulation to the granule cells at low, steady rates. Consistent with the presence of opioid-like immunoreactivity in the granule cell mossy fiber pathway, intraperitoneal injection of the opiate antagonist naloxone diminishes granule cell self-stimulation in a dose-related fashion. The results suggest that a granule cell opioid synapse participates in expression of reward at this site.

AB - Male albino rats implanted with a chronic stimulating electrode electrophysiologically guided into the granule cell layer of the dorsal dentate gyrus were tested in a self-stimulation paradigm. It was found that subjects self-administer electrical stimulation to the granule cells at low, steady rates. Consistent with the presence of opioid-like immunoreactivity in the granule cell mossy fiber pathway, intraperitoneal injection of the opiate antagonist naloxone diminishes granule cell self-stimulation in a dose-related fashion. The results suggest that a granule cell opioid synapse participates in expression of reward at this site.

UR - http://www.scopus.com/inward/record.url?scp=0021702574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021702574&partnerID=8YFLogxK

U2 - 10.1016/S0163-1047(84)90472-2

DO - 10.1016/S0163-1047(84)90472-2

M3 - Article

C2 - 6095804

AN - SCOPUS:0021702574

SN - 0163-1047

VL - 42

SP - 85

EP - 90

JO - Behavioral and Neural Biology

JF - Behavioral and Neural Biology

IS - 1

ER -

Electrical self-stimulation of dentate gyrus granule cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this