Electro-acupuncture upregulates CGRP expression after rat spinal cord transection

Wen Jie Li; Shu Min Li; Ying Ding; Bing He; Jack Keegan; Hongxin Dong; Jing Wen Ruan; Yuan Shan Zeng

doi:10.1016/j.neuint.2012.10.002

Electro-acupuncture upregulates CGRP expression after rat spinal cord transection

Wen Jie Li, Shu Min Li, Ying Ding, Bing He, Jack Keegan, Hongxin Dong, Jing Wen Ruan^*, Yuan Shan Zeng

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically.

Original language	English (US)
Pages (from-to)	1397-1403
Number of pages	7
Journal	Neurochemistry International
Volume	61
Issue number	8
DOIs	https://doi.org/10.1016/j.neuint.2012.10.002
State	Published - Dec 2012

Keywords

Calcitonin gene-related peptide
Cerebellar granule neurons
Electro-acupuncture
Neuroprotection
Spinal cord injury

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1016/j.neuint.2012.10.002

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title = "Electro-acupuncture upregulates CGRP expression after rat spinal cord transection",

abstract = "Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically.",

keywords = "Calcitonin gene-related peptide, Cerebellar granule neurons, Electro-acupuncture, Neuroprotection, Spinal cord injury",

author = "Li, {Wen Jie} and Li, {Shu Min} and Ying Ding and Bing He and Jack Keegan and Hongxin Dong and Ruan, {Jing Wen} and Zeng, {Yuan Shan}",

note = "Funding Information: This work was supported by Natural Science Foundation of Guangdong Province , (No. 07001682 ) and Social Developmental Foundation of Guangdong Province (No. 2010B030700008 ) to J.W. Ruan, and Chinese National Natural Science Foundation (No. 30973721 ) and National 863 Project (No. 2011A030300004 ) to Y.S. Zeng, and Chinese National Natural Science Foundation (No. 81102646 ) and Natural Science Foundation of Guangdong Province (No. S2011040004895 ) to Y. Ding.",

year = "2012",

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doi = "10.1016/j.neuint.2012.10.002",

language = "English (US)",

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AU - Li, Wen Jie

AU - Li, Shu Min

AU - Ding, Ying

AU - He, Bing

AU - Keegan, Jack

AU - Dong, Hongxin

AU - Ruan, Jing Wen

AU - Zeng, Yuan Shan

N1 - Funding Information: This work was supported by Natural Science Foundation of Guangdong Province , (No. 07001682 ) and Social Developmental Foundation of Guangdong Province (No. 2010B030700008 ) to J.W. Ruan, and Chinese National Natural Science Foundation (No. 30973721 ) and National 863 Project (No. 2011A030300004 ) to Y.S. Zeng, and Chinese National Natural Science Foundation (No. 81102646 ) and Natural Science Foundation of Guangdong Province (No. S2011040004895 ) to Y. Ding.

PY - 2012/12

Y1 - 2012/12

N2 - Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically.

AB - Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically.

KW - Calcitonin gene-related peptide

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KW - Electro-acupuncture

KW - Neuroprotection

KW - Spinal cord injury

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Electro-acupuncture upregulates CGRP expression after rat spinal cord transection

Abstract

Keywords

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