Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action

James R. Ames*, Peter Kovacic, Pankaja K. Kadaba, Patrick F. Kiser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.

Original languageEnglish (US)
Pages (from-to)936-943
Number of pages8
JournalEpilepsia
Volume33
Issue number5
DOIs
StatePublished - Jan 1 1992

Keywords

  • Anticonvulsants
  • Electron transfer
  • Iminium ions
  • Reduction potentials

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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