Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action

James R. Ames; Peter Kovacic; Pankaja K. Kadaba; Patrick F. Kiser

doi:10.1111/j.1528-1157.1992.tb02204.x

Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action

James R. Ames^*, Peter Kovacic, Pankaja K. Kadaba, Patrick F. Kiser

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.

Original language	English (US)
Pages (from-to)	936-943
Number of pages	8
Journal	Epilepsia
Volume	33
Issue number	5
DOIs	https://doi.org/10.1111/j.1528-1157.1992.tb02204.x
State	Published - Sep 1992

Keywords

Anticonvulsants
Electron transfer
Iminium ions
Reduction potentials

ASJC Scopus subject areas

Clinical Neurology
Neurology

Access to Document

10.1111/j.1528-1157.1992.tb02204.x

Cite this

@article{02d5f7311c004007827a6fb6badcf427,

title = "Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action",

abstract = "Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.",

keywords = "Anticonvulsants, Electron transfer, Iminium ions, Reduction potentials",

author = "Ames, {James R.} and Peter Kovacic and Kadaba, {Pankaja K.} and Kiser, {Patrick F.}",

year = "1992",

month = sep,

doi = "10.1111/j.1528-1157.1992.tb02204.x",

language = "English (US)",

volume = "33",

pages = "936--943",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Electrochemistry of Anticonvulsants

T2 - Electron Transfer as a Possible Mode of Action

AU - Ames, James R.

AU - Kovacic, Peter

AU - Kadaba, Pankaja K.

AU - Kiser, Patrick F.

PY - 1992/9

Y1 - 1992/9

N2 - Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.

AB - Summary: Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3‐triazoles, and copper complexes. The values generally were in the range of about 0.1 to 0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about 0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some anti‐epileptic agents with no electrochemical data based on this hypothetical ET approach.

KW - Anticonvulsants

KW - Electron transfer

KW - Iminium ions

KW - Reduction potentials

UR - http://www.scopus.com/inward/record.url?scp=0026793907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026793907&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1157.1992.tb02204.x

DO - 10.1111/j.1528-1157.1992.tb02204.x

M3 - Article

C2 - 1396439

AN - SCOPUS:0026793907

SN - 0013-9580

VL - 33

SP - 936

EP - 943

JO - Epilepsia

JF - Epilepsia

IS - 5

ER -

Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this