Electrocochleography during Translabyrinthine Approach for Vestibular Schwannoma Removal

William J. Riggs*, Douglas C. Fitzpatrick, Jameson K. Mattingly, Michael S. Harris, Meghan M. Hiss, Shashank Rajkumar, Kevin Y. Zhan, Kevin D. Brown, Aaron C. Moberly, Edward E. Dodson, Oliver F. Adunka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Hypothesis:Intraoperative electrocochleography (ECochG) can differentiate hair cell and neural dysfunction caused by a vestibular schwannoma (VS) and help define the site of lesion as peripheral or central to the spiral ganglion.Background:Hearing loss in patients with a VS can be caused by both sensory (cochlear) and neural dysfunction.Methods:Round-window ECochG using low and high-frequency tone bursts was performed in 49 subjects with a VS. Responses were analyzed for magnitude, spectrum, and shape of the time waveform. Components examined included the cochlear microphonic, auditory nerve neurophonic, compound action potential (CAP), and summating potential (SP).Results:Variability in the summed response magnitudes across frequency, or "total response" (ECochG-TR), varied from 0.1 to 100μV. Responses were larger for lower frequencies. Subjective estimates revealed a wide range of neural contributions from the auditory nerve neurophonic to low frequencies and the CAP to high frequencies. Cases with larger CAPs had smaller SPs. The correlation of ECochG-TR, with word recognition score (WRS), was moderate (r=0.67), as well as the correlation between pure-tone averages and ECochG (r=0.63). The cochlea remained functional in two cases of sudden sensorineural hearing loss with 0% WRS.Conclusion:Reduced ECochG-TR and neural activity in many cases indicates both sensory and neural deficits. Smaller SPs when CAPs are present indicate a neural contribution to the SP. Good cochlear function with 0% WRS, and cases of sudden sensorineural hearing loss with retained cochlear function, indicate retrocochlear effects, typically proximal to the spiral ganglion cells.

Original languageEnglish (US)
Pages (from-to)e369-e377
JournalOtology and Neurotology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • Auditory nerve neurophonic
  • Electrocochleography
  • Intraoperative
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Sensory Systems
  • Otorhinolaryngology

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