Electrode activation sequencing employing conductivity changes in irreversible electroporation tissue ablation

Alan Varteres Sahakian*, Haitham M. Al-Angari, Oyinlolu O. Adeyanju

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Irreversible electroporation (IRE) uses high-voltage pulses applied to tissue, which cause dielectric breakdown of cell membranes resulting in cell death. IRE is a promising technique for ablation of nonresectable tumors because it can be configured to spare critical structures such as blood vessels. A consequence of pulse application is an increase in tissue electrical conductivity due to current pathways being opened in cell membranes. We propose a novel IRE method introducing electrode switching and pulse sequencing in which tissue conductivity is first increased using preparatory pulses in order to form high-conductivity zones, which then helps provide higher electric field intensity within the targeted tissue as subsequent pulses are applied, and hence, enhances the efficiency and selectivity of the IRE treatment. We demonstrate the potential of this method using computational models on simple geometries.

Original languageEnglish (US)
Article number6111270
Pages (from-to)604-607
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Ablation
  • electrical conductivity
  • finite-element modeling (FEM)
  • irreversible electroporation (IRE)
  • tumor

ASJC Scopus subject areas

  • Biomedical Engineering

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