Electrodiffusion model of rectangular current pulses in ionic channels of cellular membranes

Carl L. Gardner*, Joseph W. Jerome, Robert S. Eisenberg

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A simplified electrodiffusion model for rectangular current pulses in ionic channels of biological membranes is presented. Numerical simulations and a dynamical systems analysis of traveling wave solutions in the model indicate that the durations and separations of current pulses vary stochastically in time, as is observed experimentally. An electrodiffusion theory of the mechanism for gating is advanced.

Original languageEnglish (US)
Pages (from-to)792-802
Number of pages11
JournalSIAM Journal on Applied Mathematics
Volume61
Issue number3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Dynamical systems
  • Electrodiffusion model
  • Ionic channels

ASJC Scopus subject areas

  • Applied Mathematics

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