Electrokinetic properties of the mammalian tectorial membrane

Roozbeh Ghaffari, Scott L. Page, Shirin Farrahi, Jonathan B. Sellon, Dennis M. Freeman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The tectorial membrane (TM) clearly plays a mechanical role in stimulating cochlear sensory receptors, but the presence of fixed charge in TM constituents suggests that electromechanical properties also may be important. Here, we measure the fixed charge density of the TM and show that this density of fixed charge is sufficient to affect mechanical properties and to generate electrokinetic motions. In particular, alternating currents applied to the middle and marginal zones of isolated TM segments evoke motions at audio frequencies (1-1,000 Hz). Electrically evoked motions are nanometer scaled (∼5-900 nm), decrease with increasing stimulus frequency, and scale linearly over a broad range of electric field amplitudes (0.05-20 kV/m). These findings show that the mammalian TM is highly charged and suggest the importance of a unique TM electrokinetic mechanism.

Original languageEnglish (US)
Pages (from-to)4279-4284
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number11
DOIs
StatePublished - Mar 12 2013

Keywords

  • Cochlear amplification
  • Cochlear mechanics
  • Mechanoelectrical transduction
  • Motility

ASJC Scopus subject areas

  • General

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