Electromechanical characterization of biomimetic membranes using electrodeformation of vesicles

Hammad A. Faizi, Rumiana Dimova, Petia M. Vlahovska*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We describe a facile method to simultaneously measure the bending rigidity and capacitance of biomimetic lipid bilayers. Our approach utilizes the ellipsoidal deformation of quasi-spherical giant unilamellar vesicles induced by a uniform AC electric field. Vesicle shape depends on the electric field frequency and amplitude. Membrane bending rigidity can be obtained from the variation of the vesicle elongation on either field amplitude at fixed frequency or frequency at fixed field amplitude. Membrane capacitance is determined from the frequency at which the vesicle shape changes from prolate to oblate ellipsoid as the frequency is increased at a given field amplitude.

Original languageEnglish (US)
Pages (from-to)2027-2032
Number of pages6
Issue number20
StatePublished - Oct 2021


  • Bending rigidity
  • Electrodeformation
  • Lipid bilayers
  • Membrane capacitance

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry


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