Electron transfer in DNA: Covalent attachment of spectroscopically unique donor and acceptor complexes

Elizabeth S. Krider, Thomas J. Meade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The notion that DNA is capable of electron transfer (ET) has inspired several groups to investigate the nature of this intriguing process. While several factors modulate ET reaction rates, the distance dependence of ET in DNA is the focus of our current investigations. To this end we propose that several design criteria must be met to facilitate the collection of kinetic data corresponding to DNA-mediated ET reactions. These criteria include (1) covalent attachment of site-selective donor-acceptor pairs, (2) incorporation of donor-acceptor pairs that offer minimal structural perturbation of the DNA duplex, and (3) use of spectroscopically distinguishable donor and acceptor complexes that allow identification of kinetic intermediates.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalJournal of Biological Inorganic Chemistry
Volume3
Issue number2
DOIs
StatePublished - Apr 1998

Keywords

  • DNA
  • Distance dependence
  • Electron-transfer reactions
  • Ruthenium complexes

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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