Electronic Control of Ferroporphyrin Ligand-Binding Kinetics

Marlene A. Stanford, James C. Swartz, Terry E. Phillips, Brian M. Hoffman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Measurements of the rates of CO binding to ferrous porphyrins have been used to examine two different mechanisms which have been proposed to explain protein control of heme reactivity. The results indicate that electronic control through ω-donor/acceptor interactions with the macrocyclic porphyrin ring is not important in controlling the heme reactivity of hemoglobin or of other hemoproteins. However, hydrogen bonding to the metal-bound imidazole can have a powerful influence on heme reactivity.

Original languageEnglish (US)
Pages (from-to)4492-4499
Number of pages8
JournalJournal of the American Chemical Society
Volume102
Issue number13
DOIs
StatePublished - Jun 1980

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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