TY - JOUR
T1 - Electrophysiologic effects of atropine on human sinus node and atrium
AU - Dhingra, Ramesh C.
AU - Amat-Y-Leon, Fernando
AU - Wyndham, Christopher
AU - Denes, Pablo
AU - Wu, Delon
AU - Pouget, J. Maurice
AU - Rosen, Kenneth M.
N1 - Funding Information:
From the Cardiology Section, Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois College of Medicine and West Side Veterans Administration Hospital, Chicago, III. This study was supportetl in part by Contract 71-2478 and Grant HL 18794-01 from the National Institutes of Health and Training Grant HL-05879-0581 from the U. S. Public Health Service, Bethesda, Md. and Basic Institutional Support of the West Side Veterans Administration Hospital, Chicago, Ill. Manuscript received January 8. 1976; revised manuscript received March 29, 1976, accepted March 31, 1976. Address for reprints: Ramesh C. Dhingra, MD, Cardiology Section, University of Illinois Hospital, P.O. Box 6998, Chicago, Ill. 60680.
PY - 1976/10
Y1 - 1976/10
N2 - Electrophysiologic studies were conducted in 17 patients without apparent sinus node disease before and after intravenous administration of 1 to 2 mg of atropine. Mean values in milliseconds (± standard error of the mean) before and after administration of atropine were as follows: sinus cycle length 846 ± 26.4 versus 647 ± 20.0 (P <0.001); sinus nodal recovery time 1,029 ± 37 versus 774 ± 36 (P <0.001); mean calculated sinoatrial (S-A) conduction time 103 ± 5.7 versus 58 ± 3.9 (P <0.001); mean P-A interval 34 ± 1.5 msec versus 31 ± 1.5 (P < 0.05); mean atrial effective and functional refractory periods during sinus rhythm 285 ±11.3 versus 238 ± 7.9 and 331 ± 11.6 versus 280 ± 8.6, respectively (P <0.001 for both); mean atrial effective and functional refractory periods measured at equivalent driven cycle length 239 ± 7.7 versus 213 ± 7.4 and 277 ±11.4 versus 245 ± 9.5, respectively (P <0.001 for both). In conclusion, atropine shortened sinus cycle length, sinus nodal recovery time and calculated S-A conduction time. The shortening of atrial refractory periods with atropine implies that vagotonia prolongs atrial refractoriness in man.
AB - Electrophysiologic studies were conducted in 17 patients without apparent sinus node disease before and after intravenous administration of 1 to 2 mg of atropine. Mean values in milliseconds (± standard error of the mean) before and after administration of atropine were as follows: sinus cycle length 846 ± 26.4 versus 647 ± 20.0 (P <0.001); sinus nodal recovery time 1,029 ± 37 versus 774 ± 36 (P <0.001); mean calculated sinoatrial (S-A) conduction time 103 ± 5.7 versus 58 ± 3.9 (P <0.001); mean P-A interval 34 ± 1.5 msec versus 31 ± 1.5 (P < 0.05); mean atrial effective and functional refractory periods during sinus rhythm 285 ±11.3 versus 238 ± 7.9 and 331 ± 11.6 versus 280 ± 8.6, respectively (P <0.001 for both); mean atrial effective and functional refractory periods measured at equivalent driven cycle length 239 ± 7.7 versus 213 ± 7.4 and 277 ±11.4 versus 245 ± 9.5, respectively (P <0.001 for both). In conclusion, atropine shortened sinus cycle length, sinus nodal recovery time and calculated S-A conduction time. The shortening of atrial refractory periods with atropine implies that vagotonia prolongs atrial refractoriness in man.
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U2 - 10.1016/0002-9149(76)90458-6
DO - 10.1016/0002-9149(76)90458-6
M3 - Article
C2 - 184704
AN - SCOPUS:0017125280
SN - 0002-9149
VL - 38
SP - 429
EP - 434
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 4
ER -