Electroporation of the heart

Vladimir P. Nikolski; Igor R. Efimov

doi:10.1016/j.eupc.2005.04.011

Electroporation of the heart

Vladimir P. Nikolski, Igor R. Efimov^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According to the excitation theory of defibrillation, such shocks are aimed at depolarizing the membranes of most cardiac cells resulting in resynchronization of electrical activity in the heart. If shock-induced changes in transmembrane potential are large enough, they can cause transient tissue damage due to electroporation. In this review evidence is presented that (a) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field, and (b) electroporation can affect the outcome of defibrillation therapy; being both pro- and anti-arrhythmic.

Original language	English (US)
Pages (from-to)	S146-S154
Journal	Europace
Volume	7
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/j.eupc.2005.04.011
State	Published - Sep 2005

Keywords

Defibrillation
Electroporation
Optical mapping

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.eupc.2005.04.011

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title = "Electroporation of the heart",

abstract = "Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According to the excitation theory of defibrillation, such shocks are aimed at depolarizing the membranes of most cardiac cells resulting in resynchronization of electrical activity in the heart. If shock-induced changes in transmembrane potential are large enough, they can cause transient tissue damage due to electroporation. In this review evidence is presented that (a) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field, and (b) electroporation can affect the outcome of defibrillation therapy; being both pro- and anti-arrhythmic.",

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AU - Efimov, Igor R.

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AB - Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According to the excitation theory of defibrillation, such shocks are aimed at depolarizing the membranes of most cardiac cells resulting in resynchronization of electrical activity in the heart. If shock-induced changes in transmembrane potential are large enough, they can cause transient tissue damage due to electroporation. In this review evidence is presented that (a) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field, and (b) electroporation can affect the outcome of defibrillation therapy; being both pro- and anti-arrhythmic.

KW - Defibrillation

KW - Electroporation

KW - Optical mapping

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Electroporation of the heart

Abstract

Keywords

ASJC Scopus subject areas

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