Electrostatic control of bioactivity

Joshua E. Goldberger, Eric J. Berns, Ronit Bitton, Christina J. Newcomb, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

Original languageEnglish (US)
Pages (from-to)6292-6295
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number28
StatePublished - Jul 4 2011


  • aggregation
  • biological activity
  • nanostructures
  • peptides
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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