Elements involved in the regulation of the StAR gene

Douglas M. Stocco*, Barbara J. Clark, Adam J. Reinhart, Simon C. Williams, Matthew Dyson, Barbara Dassi, Lance P. Walsh, Pulak R. Manna, XingJia Wang, Anthony J. Zeleznik, Joseph Orly

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume177
Issue number1-2
DOIs
StatePublished - May 25 2001

Keywords

  • Arachidonic acid
  • C/EBP
  • CREB
  • DAX-1
  • SF-1
  • StAR
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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