Elements involved in the regulation of the StAR gene

Douglas M. Stocco; Barbara J. Clark; Adam J. Reinhart; Simon C. Williams; Matthew Dyson; Barbara Dassi; Lance P. Walsh; Pulak R. Manna; XingJia Wang; Anthony J. Zeleznik; Joseph Orly

doi:10.1016/S0303-7207(01)00423-3

Elements involved in the regulation of the StAR gene

Douglas M. Stocco^*, Barbara J. Clark, Adam J. Reinhart, Simon C. Williams, Matthew Dyson, Barbara Dassi, Lance P. Walsh, Pulak R. Manna, XingJia Wang, Anthony J. Zeleznik, Joseph Orly

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	Molecular and Cellular Endocrinology
Volume	177
Issue number	1-2
DOIs	https://doi.org/10.1016/S0303-7207(01)00423-3
State	Published - May 25 2001

Funding

The authors would like to acknowledge the support of NIH grant HD-17481 (to DMS), the United States–Israel Binational Sciences Foundation Grant 95-00350 and The Israel Science Foundation founded by the Israel Academy of Sciences and Humanities (#547/97) (to J.O.), NIH grant DK-51656 (to B.J.C.), NIH grant HD-16842 (to A.J.Z.) and NIH grant HD-07271 (which supported L.P.W.).

Keywords

Arachidonic acid
C/EBP
CREB
DAX-1
SF-1
StAR
Transcription factors

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Biochemistry

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10.1016/S0303-7207(01)00423-3

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title = "Elements involved in the regulation of the StAR gene",

abstract = "The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.",

keywords = "Arachidonic acid, C/EBP, CREB, DAX-1, SF-1, StAR, Transcription factors",

author = "Stocco, {Douglas M.} and Clark, {Barbara J.} and Reinhart, {Adam J.} and Williams, {Simon C.} and Matthew Dyson and Barbara Dassi and Walsh, {Lance P.} and Manna, {Pulak R.} and XingJia Wang and Zeleznik, {Anthony J.} and Joseph Orly",

note = "Funding Information: The authors would like to acknowledge the support of NIH grant HD-17481 (to DMS), the United States–Israel Binational Sciences Foundation Grant 95-00350 and The Israel Science Foundation founded by the Israel Academy of Sciences and Humanities (#547/97) (to J.O.), NIH grant DK-51656 (to B.J.C.), NIH grant HD-16842 (to A.J.Z.) and NIH grant HD-07271 (which supported L.P.W.). Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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AU - Clark, Barbara J.

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AU - Williams, Simon C.

AU - Dyson, Matthew

AU - Dassi, Barbara

AU - Walsh, Lance P.

AU - Manna, Pulak R.

AU - Wang, XingJia

AU - Zeleznik, Anthony J.

AU - Orly, Joseph

N1 - Funding Information: The authors would like to acknowledge the support of NIH grant HD-17481 (to DMS), the United States–Israel Binational Sciences Foundation Grant 95-00350 and The Israel Science Foundation founded by the Israel Academy of Sciences and Humanities (#547/97) (to J.O.), NIH grant DK-51656 (to B.J.C.), NIH grant HD-16842 (to A.J.Z.) and NIH grant HD-07271 (which supported L.P.W.). Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2001/5/25

Y1 - 2001/5/25

N2 - The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.

AB - The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.

KW - Arachidonic acid

KW - C/EBP

KW - CREB

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KW - SF-1

KW - StAR

KW - Transcription factors

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Elements involved in the regulation of the StAR gene

Abstract

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Keywords

ASJC Scopus subject areas

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