Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants

Christopher J. Rhee*, Jeffrey R. Kaiser, Danielle R. Rios, Kathleen K. Kibler, R. Blaine Easley, Dean B. Andropoulos, Marek Czosnyka, Peter Smielewski, Georgios V. Varsos, Craig G. Rusin, C. Heath Gauss, D. Keith Williams, Kenneth Martin Brady

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective To determine whether the diastolic closing margin (DCM), defined as diastolic blood pressure minus critical closing pressure, is associated with the development of early severe intraventricular hemorrhage (IVH). Study design A reanalysis of prospectively collected data was conducted. Premature infants (gestational age 23-31 weeks) receiving mechanical ventilation (n = 185) had ∼1-hour continuous recordings of umbilical arterial blood pressure, middle cerebral artery cerebral blood flow velocity, and PaCO 2 during the first week of life. Models using multivariate generalized linear regression and purposeful selection were used to determine associations with severe IVH. Results Severe IVH (grades 3-4) was observed in 14.6% of the infants. Irrespective of the model used, Apgar score at 5 minutes and DCM were significantly associated with severe IVH. A clinically relevant 5-mm Hg increase in DCM was associated with a 1.83- to 1.89-fold increased odds of developing severe IVH. Conclusion Elevated DCM was associated with severe IVH, consistent with previous animal data showing that IVH is associated with hyperperfusion. Measurement of DCM may be more useful than blood pressure in defining cerebral perfusion in premature infants.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalJournal of Pediatrics
Volume174
DOIs
StatePublished - Jul 1 2016

Keywords

  • arterial blood pressure
  • cerebral blood flow
  • critical closing pressure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Rhee, C. J., Kaiser, J. R., Rios, D. R., Kibler, K. K., Easley, R. B., Andropoulos, D. B., Czosnyka, M., Smielewski, P., Varsos, G. V., Rusin, C. G., Gauss, C. H., Williams, D. K., & Brady, K. M. (2016). Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants. Journal of Pediatrics, 174, 52-56. https://doi.org/10.1016/j.jpeds.2016.03.066