Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

David E. Leaf, Myles Wolf, Leonard Stern*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D3-1α-hydroxylase, could explain the deficiency of 1,25(OH)2D3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

Original languageEnglish (US)
Pages (from-to)1335-1337
Number of pages3
JournalNephrology Dialysis Transplantation
Volume25
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • ARF
  • Hyperparathyroidism
  • Hyperphosphataemia
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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