Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

David E. Leaf; Myles Wolf; Leonard Stern

doi:10.1093/ndt/gfp682

Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

David E. Leaf, Myles Wolf, Leonard Stern^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D3-1α-hydroxylase, could explain the deficiency of 1,25(OH)2D3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

Original language	English (US)
Pages (from-to)	1335-1337
Number of pages	3
Journal	Nephrology Dialysis Transplantation
Volume	25
Issue number	4
DOIs	https://doi.org/10.1093/ndt/gfp682
State	Published - Apr 2010
Externally published	Yes

Keywords

ARF
Hyperparathyroidism
Hyperphosphataemia
Vitamin D

ASJC Scopus subject areas

Nephrology
Transplantation

Access to Document

10.1093/ndt/gfp682

Cite this

@article{cefb60a949964365bacf83e6d491a56e,

title = "Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury",

abstract = "Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D3-1α-hydroxylase, could explain the deficiency of 1,25(OH)2D3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.",

keywords = "ARF, Hyperparathyroidism, Hyperphosphataemia, Vitamin D",

author = "Leaf, {David E.} and Myles Wolf and Leonard Stern",

year = "2010",

month = apr,

doi = "10.1093/ndt/gfp682",

language = "English (US)",

volume = "25",

pages = "1335--1337",

journal = "Nephrology Dialysis Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

AU - Leaf, David E.

AU - Wolf, Myles

AU - Stern, Leonard

PY - 2010/4

Y1 - 2010/4

N2 - Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D3-1α-hydroxylase, could explain the deficiency of 1,25(OH)2D3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

AB - Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D3-1α-hydroxylase, could explain the deficiency of 1,25(OH)2D3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

KW - ARF

KW - Hyperparathyroidism

KW - Hyperphosphataemia

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=77950282848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950282848&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfp682

DO - 10.1093/ndt/gfp682

M3 - Article

C2 - 20037176

AN - SCOPUS:77950282848

SN - 0931-0509

VL - 25

SP - 1335

EP - 1337

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

IS - 4

ER -

Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this