Elevated levels of monocyte activation markers are associated with subclinical atherosclerosis in men with and those without HIV infection

Rebeccah A. McKibben, Joseph B. Margolick, Steven Grinspoon, Xiuhong Li, Frank J. Palella, Lawrence A. Kingsley, Mallory D. Witt, Richard T. George, Lisa P. Jacobson, Matthew Budoff, Russell P. Tracy, Todd T. Brown, Wendy S. Post*

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Background Heightened immune activation among human immunodeficiency virus (HIV)-infected persons may contribute to atherosclerosis. We assessed associations of serologic markers of monocyte activation, soluble CD163 (sCD163) and soluble CD14 (sCD14), and monocyte chemoattractant protein 1 (CCL2) with subclinical atherosclerosis among men with and those without HIV infection in the Multicenter AIDS Cohort Study. Methods. We performed noncontrast computed tomography on 906 men (566 HIV-infected men and 340 HIV-uninfected men), 709 of whom also underwent coronary computed tomographic angiography. Associations between each biomarker and the prevalence of coronary plaque, the prevalence of stenosis of ≥ 50%, and the extent of plaque were assessed by logistic and linear regression, adjusting for age, race, HIV serostatus, and cardiovascular risk factors. Results. Levels of all biomarkers were higher among HIV-infected men, of whom 81% had undetectable HIV RNA, and were associated with lower CD4 + T-cell counts. In the entire population and among HIV-infected men, higher biomarker levels were associated with a greater prevalence of coronary artery stenosis of ≥ 50%. Higher sCD163 levels were also associated with greater prevalences of coronary artery calcium, mixed plaque, and calcified plaque; higher CCL2 levels were associated with a greater extent of noncalcified plaque. Conclusions. sCD163, sCD14, and CCL2 levels were elevated in treated HIV-infected men and associated with atherosclerosis. Monocyte activation may increase the risk for cardiovascular disease in individuals with HIV infection.

Original languageEnglish (US)
Pages (from-to)1219-1228
Number of pages10
JournalJournal of Infectious Diseases
Volume211
Issue number8
DOIs
StatePublished - Apr 15 2015

Keywords

  • atherosclerosis
  • human immunodeficiency virus
  • inflammation
  • monocyte activation
  • plaque

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    McKibben, R. A., Margolick, J. B., Grinspoon, S., Li, X., Palella, F. J., Kingsley, L. A., Witt, M. D., George, R. T., Jacobson, L. P., Budoff, M., Tracy, R. P., Brown, T. T., & Post, W. S. (2015). Elevated levels of monocyte activation markers are associated with subclinical atherosclerosis in men with and those without HIV infection. Journal of Infectious Diseases, 211(8), 1219-1228. https://doi.org/10.1093/infdis/jiu594